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課程名稱 |
物理化學上
PHYSICAL CHEMISTRY (1) |
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開課學期 |
96-1 |
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授課對象 |
農業化學系 |
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授課教師 |
黃良平 |
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課號 |
Chem3007 |
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課程識別碼 |
203 33101 |
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班次 |
01 |
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學分 |
3 |
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全/半年 |
全年 |
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必/選修 |
必帶 |
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上課時間 |
星期一5(12:20~13:10)星期四1,2(8:10~10:00) |
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上課地點 |
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備註 |
詳化學系選課須知, 與生技系併班上課。教室在綜302
總人數上限：120人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/961biophychem |
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課程簡介影片 |
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核心能力關聯 |
本課程尚未建立核心能力關連 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
（I）氣體、液體、熱力學三大定律，自由能及化學平衡，溶液論，電化學及表面熱力學。
（II）測不準原理，機率概念，Schr(a0c9)dinger 方程式，運算子，角動量，盒中質點運動，長方井中質點運動，簡諧運動，氫原子，變量法，微擾法。
（III）基本動力學概念、動力學數據分析、活化能、反應速率原理、基本氣相反應、溶液中之基本反應、綜合反應、均相催化、同位素效應、反應動力學。
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課程目標 |
Thermodynamics of solutions: introduction to First and Second Laws. Gibbs function, chemical potential and electrochemical potential. Osmotic equilibria; chemical equilibria; redox equilibria. Buffer solutions and pH. Non-ideal solutions: activity co-efficients. Debye-Huckel theory. Solubility of proteins and other compounds.
Principles of Newtonian mechanics and electrostatics. Quantum theory: concepts of quantum mechanics in terms of energy levels. Boltzmann distribution. Atomic and molecular structure, atomic orbitals: crystal field theory; LCAO approach to molecular orbitals.
Electromagnetic radiation and its interaction with matter. Light absorption. Spectroscopy, Beer's Law. Diffraction; Bragg's Law. X-ray diffraction by crystals. Modern optical microscopy. Electron microscopy.
Kinetics: order and molecularity; first, second, and pseudo-first order kinetics, steady state. Half lives. Theories of reaction rates; collision theory, transition state theory. Activation energy and the Arrhenius equation. Isotope effects, acid-base catalysis. Radioactive decay as a first order process. Biological effects of radiation.
Enzyme kinetics, Michaelis-Menten equation and the steady state derivation. Irreversible and reversible inhibitors of enzymes. Classification of reversible inhibitors. Allostery.
Non-covalent interactions. Electrostatic forces and dipoles. Electronegativity. Lennard-Jones potential and van der Waal's radii. Hydrogen bonding in proteins, DNA and oligosaccharides. The hydrophobic effect; role of entropy. Accessible surface area and solubility. Protein folding—thermodynamic and kinetic aspects. Co-operativity of folding. Protein denaturation and misfolding. |
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課程要求 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
Physical Chemistry for the Life Sciences,
Thomas Engel
購買請洽「歐亞書局」 02-8912-1188
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評量方式
(僅供參考) |
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