課程資訊
課程名稱
有機化學乙上
ORGANIC CHEMISTRY (B)(1) 
開課學期
98-1 
授課對象
藥學系  
授課教師
羅禮強 
課號
Chem2025 
課程識別碼
203 222B1 
班次
01 
學分
全/半年
全年 
必/選修
必修 
上課時間
星期二3,4(10:20~12:10)星期四3,4(10:20~12:10) 
上課地點
新405新405 
備註
請依指定修習院系班次修習,請詳閱化學系選課需知。先修:普化
限本系所學生(含輔系、雙修生)
總人數上限:70人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/981org01 
課程簡介影片
 
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課程概述

台灣大學99學年第一、二學期
開課系所:化學系
課程名稱:有機化學乙上/下 (Organic Chemistry B I/II)課程編號:203 222B1 班次01
授課對象:藥學系
授課老師:羅禮強 教授
上課時間:二34(普205)四34(普402)

先修科目: 普通化學
選課規定: 詳化學系選課須知
有機化學 乙 (全年課程)
有機化學一、有機化學二 (4 hours/week)


教科書:
Organic Chemistry, 9th Ed.
T. W. Graham Solomons, and Craig B. Fryhle
John Wiley & Sons, Inc.
歐亞書局:8912-1188

本課程之先修課程為普通化學,本課程的內容主要是依據所指定之教科書按時程授課,由介紹官能基的性質、命名及其轉換來入門,進而強調反應機制的重要性及有機合成在藥物開發的各種應用實例。 

課程目標
本課程為一學年分上下兩學期之課程,適合藥學系的大二學生修習,涵蓋以下綱要主題。

(1) Bonding and Molecular Structure
Structural theory of organic chemistry
Chemical bonds
Lewis structures
Formal charge
Molecular orbitals
Functional groups
(2) Acids and Bases
Carbocations and carbanions
Use of curved arrows in illustrating reactions
The strength of acids and bases
Predicting the outcome of acid-base reactions
(3) Nomenclature and Conformations of Alkanes and Cycloalkanes
IUPAC Nomenclature of organic compounds
Conformational analysis
Chemical reactions of alkanes
(4) Stereochemistry and Chirality
Biological significance of chirality
Naming stereocenters
Optical activity
Separation of enantiomers
(5) Ionic Reactions
Nucleophilic substitution of alkyl halides
Elimination reactions of alkyl halides
(6) Alkenes and Alkynes
Structure, properties and nomenclature
Synthesis of alkenes and alkynes
Addition reactions
(7) Structure Determination of Organic Compounds
Nuclear magnetic resonance
Chemical shifts and signal splitting
Mass spectrometry
(8) Radical Reactions
Homolytic bond dissociation energies
The reactions of alkanes with halogens
Radical addition to alkenes
(9) Alcohols and Ethers
Structure, properties and nomenclature
Synthesis of alcohols and ethers
Reactions of alcohols and ethers
(10) Aromatic Compounds
Nomenclature of benzene derivatives
Hückel’s rule
Reactions of aromatic compounds
Spectroscopy of aromatic compounds
(11) Aldehydes and Ketones
Nomenclature and properties of aldehydes and ketones
Synthesis of aldehydes and ketones
Nucleophilic addition to the carbon-oxygen double bond
Keto-enol tautomerism
Reactions at an (83d1)-carbon
The aldol reaction
(12) Carboxylic Acids and Their Derivatives
Structure and nomenclature
Nucleophilic addition-elimination at the acyl carbon
Acyl chlorides, anhydrides, esters, and amides
Decarboxylation
(13) (83d2)-Dicarbonyl Compounds
Claisen condensation
Acetoacetatic ester synthesis
Malonic ester synthesis
Knoevenagel condensation
Michael additions
(14) Amines
Structure, nomenclature and classification
Basicity
Reaction with acids
Synthesis of sulfa drugs
(15) Introduction to Biomolecules
Carbohydrates
Lipids
Amino acids and proteins 
課程要求
評分標準:本課程每學期將安排進行二次主要考試,期中考及期末考分別占30及40%,另依據上課進度及時程有隨堂考試與作業成績占30%,學期總成績將由此加總分數來評定。考試時學生需準時參加,並且不得有作弊的行為,除了因公務或疾病原因外(需醫院證明),缺考者該次考試成績以零分計算。 
Office Hours
 
參考書目
教科書:
Organic Chemistry, 9th Ed.
T. W. Graham Solomons, and Craig B. Fryhle
John Wiley & Sons, Inc.
歐亞書局:8912-1188 
指定閱讀
教科書:
Organic Chemistry, 9th Ed.
T. W. Graham Solomons, and Craig B. Fryhle
John Wiley & Sons, Inc.
歐亞書局:8912-1188 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題