課程資訊
課程名稱
物理化學上
PHYSICAL CHEMISTRY (1) 
開課學期
96-1 
授課對象
農業化學系  
授課教師
黃良平 
課號
Chem3007 
課程識別碼
203 33101 
班次
01 
學分
全/半年
全年 
必/選修
必帶 
上課時間
星期一5(12:20~13:10)星期四1,2(8:10~10:00) 
上課地點
 
備註
詳化學系選課須知, 與生技系併班上課。教室在綜302
總人數上限:120人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/961biophychem 
課程簡介影片
 
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課程概述

(I)氣體、液體、熱力學三大定律,自由能及化學平衡,溶液論,電化學及表面熱力學。

(II)測不準原理,機率概念,Schr(a0c9)dinger 方程式,運算子,角動量,盒中質點運動,長方井中質點運動,簡諧運動,氫原子,變量法,微擾法。

(III)基本動力學概念、動力學數據分析、活化能、反應速率原理、基本氣相反應、溶液中之基本反應、綜合反應、均相催化、同位素效應、反應動力學。 

課程目標
Thermodynamics of solutions: introduction to First and Second Laws. Gibbs function, chemical potential and electrochemical potential. Osmotic equilibria; chemical equilibria; redox equilibria. Buffer solutions and pH. Non-ideal solutions: activity co-efficients. Debye-Huckel theory. Solubility of proteins and other compounds.

Principles of Newtonian mechanics and electrostatics. Quantum theory: concepts of quantum mechanics in terms of energy levels. Boltzmann distribution. Atomic and molecular structure, atomic orbitals: crystal field theory; LCAO approach to molecular orbitals.

Electromagnetic radiation and its interaction with matter. Light absorption. Spectroscopy, Beer's Law. Diffraction; Bragg's Law. X-ray diffraction by crystals. Modern optical microscopy. Electron microscopy.

Kinetics: order and molecularity; first, second, and pseudo-first order kinetics, steady state. Half lives. Theories of reaction rates; collision theory, transition state theory. Activation energy and the Arrhenius equation. Isotope effects, acid-base catalysis. Radioactive decay as a first order process. Biological effects of radiation.

Enzyme kinetics, Michaelis-Menten equation and the steady state derivation. Irreversible and reversible inhibitors of enzymes. Classification of reversible inhibitors. Allostery.

Non-covalent interactions. Electrostatic forces and dipoles. Electronegativity. Lennard-Jones potential and van der Waal's radii. Hydrogen bonding in proteins, DNA and oligosaccharides. The hydrophobic effect; role of entropy. Accessible surface area and solubility. Protein folding—thermodynamic and kinetic aspects. Co-operativity of folding. Protein denaturation and misfolding. 
課程要求
 
Office Hours
 
參考書目
Physical Chemistry for the Life Sciences,
Thomas Engel

購買請洽「歐亞書局」 02-8912-1188 
指定閱讀
 
評量方式
(僅供參考)
   
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