課程資訊
課程名稱
高等化學生物學二
Advanced Chemical Biology (Ⅱ) 
開課學期
103-2 
授課對象
理學院  化學所化學生物學組  
授課教師
吳世雄 
課號
Chem7036 
課程識別碼
223 M1620 
班次
 
學分
全/半年
半年 
必/選修
必修 
上課時間
星期五2,3,4(9:10~12:10) 
上課地點
化121 
備註
本課程以英語授課。化學系有機組不得修習。
限碩士班以上
總人數上限:50人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1032Chem7036 
課程簡介影片
 
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課程概述

This courses aims to provide students with general knowledge in the synthesis of biomolecules, which is applied either to prepare small molecules to probe target DNA/proteins, or to develop efficient methods to study biological questions. Therefore seven weeks are used to cover the synthesis, while the remaining is to talk about famous examples. Students who want to take the course need to pass the undergraduate course of organic chemistry (two semester courses with at least 2 hours per week). 

課程目標
It is also recommended to have basic concept in biochemistry, at least to be aware of what are the structures of amino acids, nucleic acids and sugars. 
課程要求
 
Office Hours
 
參考書目
 
指定閱讀
 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第1週
02/27  No Class-Observe the 228 Memorial Day 
第2週
03/06  Antibiotics and their resistance 
第3週
03/13  From natural products to pharmaceuticals: case study 
第4週
03/20  From natural products to pharmaceuticals: case study 
第5週
03/27  Combinatorial Chemistry-Parallel synthesis & High-Throughput Drug Screening 
第6週
04/03  No Class-Observe the Tomb Sweeping Day 
第7週
04/10  Rational Design of Enzyme Inhibitors-Drug design: identification of a pharmacophore and lead optimization 
第8週
04/17  Specific labeling on biomolecules-Case study 
第9週
04/24  Midterm Exam (Dr. Wu and Dr. Li’s parts) 
第10週
05/01  Native chemical ligation and specific protein modification developed by Peter Schultz 
第11週
05/08  Native chemical ligation and specific protein modification developed by Peter Schultz 
第12週
05/15  Native chemical ligation and specific protein modification developed by Peter Schultz 
第13週
05/22  Report for evaluation 
第14週
05/29  Activity-based probes and protein profiling 
第15週
06/05  Activity-based probes and protein profiling 
第16週
06/12  Activity-based probes and protein profiling 
第17週
06/19  No Class- Observe the Dragon Boat Festival 
第18週
06/26  Final Exam (Dr. Wang and Dr. Liang’s parts)