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課程概述 |
I. Introduction:
I.a Basic of Mass Spectrometry
I.b Major Applications of Mass Spectrometry
I.c Vacuum Science and Technology
II. Ionization:
II.a Electron Ionization
II.b Chemical Ionization
II.c Photoionization
II.d Matrix-assisted Laser Desorption/Ionization
II.e Electrospray Ionization
II.f Other Ionization methods: FAB, Field Ionization, SIMS etc.
II.g Major challenges for Future Development
III. Mass Analysis:
III.a Quadrupole
III.b Ion Trap
III.c Time-of-flight
III.d Magnetic Sector
III.e FTICR
III.f Major Challenges for Future Development
IV. Detection:
IV.a Charge Collector
IV.b Charge Amplifier Detector
IV.c Scientillator Detector
IV.d Other Detectors and Major Barriers to Overome.
V. Tandem Mass Spectrometry
V.a Basic of MS/MS
V.b Collision induced Dissociation
V.c Ion-Molecule Interaction
VI. Chromatography/Mass Spectrometer Coupling
VI.a GC/MS
VI.b LC/MS
VI.c CE/MS
VII Biomolecule Analysis
VII.a Oligonucleotide, Protein, Polysaccharide Analysis
VII.b DNA Analysis and Sequencing
VII.c Proteomic & Metabolomic Applications
VII.d Disease Diagnosis
VIII Other Applications
VIII.a Trace Element Analysis
VIII.b Organic Polymer Analysis
VIII.c Environmental Application
VIII.d Material Analysis
IX Future Challenges:
I X.a Ionization Mechanism
IX.b Mass to Charge Ratio Extension
IX.c Quantitative Measurements
IX.d Dynamic Range Extension
IX.e Cost Reduction
IX.f Size Reduction
X. Conclusion
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