課程資訊
課程名稱
藥物設計與開發
DRUG DESIGN AND DEVELOPMENT 
開課學期
99-1 
授課對象
理學院  化學所化學組  
授課教師
林俊宏 
課號
Chem5058 
課程識別碼
223 U2650 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期二5,6(12:20~14:10) 
上課地點
化217 
備註
本課程中文授課,使用英文教科書。本課程中文授課,使用英文教科書。詳選課須知。外系所學生選修需經授課教師同意。
限學士班三年級以上 且 限本系所學生(含輔系、雙修生)
總人數上限:60人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/991Chem5058 
課程簡介影片
 
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課程概述

1.General aspects: Provide basic terminology and concept, including optimization of lead compounds, structure–activity relationship, oral bioavailability, and pharmacokinetics
2.Antibiotics and antibiotic resistance: Describe the discovery of penicillins and our long-standing battles against bacteria
3.Aspirins and nonsteroidal anti-inflammatory agents (NSAIDs): What happens about the sour success of selective COX-2 inhibitors?
4.Tyrosine kinase inhibitors as effective anti-cancer therapy: There are 518 kinases encoded in the human genome. Specific kinases are targeted for therapeutic development. Some of the examples and the strategies will be reviewed.
5.Hormone analogues as contraceptives and antiulcer agents : Describe the mode of action of histamine receptor antagonists (ranitidine).
6.Targeting proteases: success, failures and future prospects: Historic review of ACE inhibitors (for the treatment of hypertension) and HIV protease inhibitors (for that of AIDS)
7.Protein drugs: Most of protein drugs are glycoproteins. Why are glycosylations so important? 

課程目標
 
課程要求
Anyone qualifies for taking this course if at least either one of the conditions applies: (1) anyone who took or is taking the courses of Organic Chemistry and Biochemistry; (2) anyone who passed the course of Advanced Chemical Biology I. 
預期每週課後學習時數
 
Office Hours
 
參考書目
(a) “The Organic Chemistry of Drug Design and Drug Action” by Richard
B. Silverman (Elsevier)
(b) “Drug Discovery: A History” by Water Sneader (John Wiley)
(c) “Wilson and Gisvold’s Textbook of Organic Medicinal and
Pharmaceutical Chemistry” 11th Edition, by John H. Block and John M. Beale,
Jr. (Lippincott Williams & Wilkins)
 
指定閱讀
An introduction to Medicinal Chemistry” by Graham L. Patrick (Oxford University Press)  
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
Oral presentation 
50% 
All the students will be grouped into 7-8 groups. Each group will be assigned 1-2 papers for oral presentation (45 min power-point presentation). 
2. 
Written exams 
50% 
Evaluation will be based on students’ understanding of provided knowledge and materials 
 
課程進度
週次
日期
單元主題
第1週
9/14  General aspect I 
第2週
9/21  Antibiotics and antibiotic resistance I 
第3週
9/28  陳玉如老師 
第4週
10/05  General Aspect II 
第5週
10/12  Antibiotics and antibiotic resistance II 
第6週
10/19  Aspirins and nonsteroidal anti-inflammatory agents (NSAIDs) 
第7週
10/26  Tyrosine kinase inhibitors as effective anti-cancer therapy 
第8週
11/02  1. 分組報告的papers.
2. Tyrosine kinase inhibitors 
第9週
11/09  Midterm exam 
第10週
11/16  Hormone analogues as contraceptives and antiulcer agents 
第12週
11/30  Targeting proteases: success, failures and future prospects 
第14週
12/14  Protein drugs 
第16週
12/28  Student presentations 
第18週
1/11  Final exam