課程資訊
課程名稱
 蛋白質化學生物學
CHEMICAL BIOLOGY OF PROTEINS 
開課學期
 97-1 
授課對象
 理學院  化學所化學生物學組  
授課教師
 陳長謙 
課號
 Chem5061 
課程識別碼
 223EU2680 
班次
  
學分
 2 
全/半年
 半年 
必/選修
 選修 
上課時間
 星期二3,4(10:20~12:10) 
上課地點
 化121 
備註
 本課程以英語授課。詳選課須知。外系所學生選修需經授課教師同意。
限學士班三年級以上 且 限本系所學生(含輔系、雙修生)
總人數上限：70人 
Ceiba 課程網頁
 http://ceiba.ntu.edu.tw/971proteins 
課程簡介影片
 
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課程概述

The course is designed to introduce you to the wonderful world of proteins,
addressing such issues as
1. How proteins fold? The pathways of folding, and the forces that stabilize
protein structures.
2. How proteins are identified and their 3-dimensional structures determined?
3. How proteins are coded, synthesized, and post-translationally modified in cells?
4. How proteins are sorted? Protein and membrane trafficking in cells.
5. How proteins levels are regulated in cells? Systems biology.
6. How proteins function as enzymes, and in signal and free energy transduction?
7. Molecular basis of protein aggregation diseases. 

課程目標
 See above 
課程要求
  
預期每週課前或/與課後學習時數
  
Office Hours
  
指定閱讀
  
參考書目
 No Textbook Required 
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 Essay 
40% 
 your grade will be based on essays written (in Chinese or English) on literature articles assigned for reading. 
2. 
 Midterm Exam 
30% 
 A midterm examination has been scheduled for the course. In addition, there will be a　comprehensive final examination based on multiple-choice questions as well as questions requiring brief written responses. In order to eliminate any disadvantages or handicaps related to language, the written responses could be in English or Chinese.  
3. 
 Final Exam 
30% 
 The final is a “take home” examination requiring no more than 3 hours. It will be distributed the week of January 13, 2008, and due back on 4:00 p.m. Friday January 16th。 
  1. 本校建議 A+ 比例上限為 20% ，非強制規定，授課教師可依課程要求調整，建議必修課程參考。
  2. 本校採用等第制評定成績，學生成績評量辦法中的百分制分數區間與單科成績對照表僅供參考，授課教師可依等第定義調整分數區間。詳見學習評量專區 (連結)。
 
課程進度
週次
日期
單元主題
第1週
 09/16  Methods for the Structural Determination of Proteins.X-ray Diffraction of Protein Crystals. 
第2週
 09/23  From Amino Acid to Protein. Force that Stabilize Structural Elements and Protein Structures 
第3週
 09/30  Methods for the Structural Determination of Proteins. Multi-dimensional NMR of Proteins in Solution. 
第4週
 10/07  Thermodynamics and Kinetics of Protein Folding and Unfolding. 
第5週
 10/14  Membrane Proteins. 
第6週
 10/21  Protein Biosynthesis. 
第7週
 10/28  Co-translational Protein Folding. 
第8週
 11/04  Midterm Examination (Postponed). 
第9週
 11/11  Protein and Membrane Trafficking. 
第10週
 11/18  Protein and Membrane Trafficking 
第11週
 11/25  Proteomics 
第12週
 12/02  Systems Biology. 
第13週
 12/09  Enzymes. Michaelis-Menten Kinetics. Enzyme Mechanisms.
 
第14週
 12/16  Ion Channels and Transporters. Pumps. 
第15週
 12/23  Signaling Cascades. Protein-protein Interactions. Receptors. 
第16週
 12/30  Proteins that Interact with DNA and RNA. DNA
and RNA Polymerases. Transcription Factors.
Signal-molecule methods.
 
第17週
 01/06  Protein Mis-folding and Aggregation Diseases. Prions and Aβ.  
第18週
 01/13  Final Examination.