課程名稱 |
高等有機化學一 Advanced Organic Chemistry (Ⅰ) |
開課學期 |
109-1 |
授課對象 |
理學院 化學所化學組 |
授課教師 |
柳玗珍 |
課號 |
Chem7027 |
課程識別碼 |
223EM1230 |
班次 |
|
學分 |
4.0 |
全/半年 |
半年 |
必/選修 |
必修 |
上課時間 |
星期一3,4(10:20~12:10)星期五3,4(10:20~12:10) |
上課地點 |
化121化121 |
備註 |
本課程以英語授課。 限本系所學生(含輔系、雙修生) 且 限碩士班以上 總人數上限:30人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1091Chem7027_ |
課程簡介影片 |
|
核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
|
為確保您我的權利,請尊重智慧財產權及不得非法影印
|
課程概述 |
This course is intended to provide an overview of some reactions commonly employed in synthetic organic chemistry, with an emphasis on carbon-carbon bond forming reactions. Issues related to chemo-, regio-, and stereoselectivity are central to developing synthetic strategies and will be highlighted throughout the course.
This is 4-credit course aimed for students in the M.Sc. and Ph.D. programs in the organic division of the Department of Chemistry. |
課程目標 |
Tentative Course Outline
1. Functional Group Interconversions
– Substitutions
– Protecting Groups
– Alkene Functionalization
– Reductions
– Oxidations
2. C–C Bond Forming Reactions
– Enolate Formation/Alkylation/Aldol reactions
– Olefinations
– Addition Reactions
– Cycloaddition Reactions
– Pericyclic Reactions
– Carbenes
– Carbocations |
課程要求 |
|
預期每週課後學習時數 |
|
Office Hours |
|
指定閱讀 |
Carey, Francis A, and Richard J. Sundberg. Advanced Organic Chemistry: Part B: Reactions and Synthesis, 5th Ed. |
參考書目 |
|
評量方式 (僅供參考) |
|
週次 |
日期 |
單元主題 |
Week 1 |
|
1. Introduction and Functional Group Interconversion by Substitution, Including Protection and Deprotection (C&S Chapter 3) |
Week 2 |
|
2. Electrophilic Additions to Carbon-Carbon Multiple Bonds (C&S Chapter 4) |
Week 3 |
|
3. Reduction of Carbon-Carbon Multiple Bonds, Carbonyl Groups, and Other Functional Groups (C&S Chapter 5) |
Week 4 |
|
4. Oxidations (C&S Chapter 6) |
Week 5 |
|
5. Alkylation of Enolates and Other Carbon Nucleophiles (C&S Chapter 1) |
Week 6 |
|
Mid-Term I |
Week 7 |
|
6. Reactions of Carbon Nucleophiles with Carbonyl Compounds (C&S Chapter 2) |
Week 8 |
|
7. Carbon-Carbon Bond Forming Reactions of Compounds of Boron, Silicon, and Tin (C&S Chapter 9) |
Week 9 |
|
8. Organometallic Compounds of Group I and II Metals (C&S Chapter 7) |
Week 10 |
|
9. Concerted Cycloadditions, Unimolecular Rearrangements, and Thermal Eliminations (C&S Chapter 6) |
Week 11 |
|
Mid-Term II |
Week 12 |
|
10. Reactions Involving Carbocations, Carbenes, and Radicals and Reactive Intermediates (C&S Chapter 10) |
Week 13 |
|
11. Aromatic Substitution Reactions (C&S Chapter 11) |
Week 14 |
|
12. Reactions Involving Transition Metals (C&S Chapter 8) |
Week 15 |
|
Final Exam |
Week 16 |
|
Oral Presentation |
Week 17 |
|
Oral Presentation |
|