課程名稱 |
藥物設計與開發 DRUG DESIGN AND DEVELOPMENT |
開課學期 |
99-1 |
授課對象 |
理學院 化學所化學組 |
授課教師 |
林俊宏 |
課號 |
Chem5058 |
課程識別碼 |
223 U2650 |
班次 |
|
學分 |
2 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期二5,6(12:20~14:10) |
上課地點 |
化217 |
備註 |
本課程中文授課,使用英文教科書。本課程中文授課,使用英文教科書。詳選課須知。外系所學生選修需經授課教師同意。 限學士班三年級以上 且 限本系所學生(含輔系、雙修生) 總人數上限:60人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/991Chem5058 |
課程簡介影片 |
|
核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
|
為確保您我的權利,請尊重智慧財產權及不得非法影印
|
課程概述 |
1.General aspects: Provide basic terminology and concept, including optimization of lead compounds, structure–activity relationship, oral bioavailability, and pharmacokinetics
2.Antibiotics and antibiotic resistance: Describe the discovery of penicillins and our long-standing battles against bacteria
3.Aspirins and nonsteroidal anti-inflammatory agents (NSAIDs): What happens about the sour success of selective COX-2 inhibitors?
4.Tyrosine kinase inhibitors as effective anti-cancer therapy: There are 518 kinases encoded in the human genome. Specific kinases are targeted for therapeutic development. Some of the examples and the strategies will be reviewed.
5.Hormone analogues as contraceptives and antiulcer agents : Describe the mode of action of histamine receptor antagonists (ranitidine).
6.Targeting proteases: success, failures and future prospects: Historic review of ACE inhibitors (for the treatment of hypertension) and HIV protease inhibitors (for that of AIDS)
7.Protein drugs: Most of protein drugs are glycoproteins. Why are glycosylations so important? |
課程目標 |
|
課程要求 |
Anyone qualifies for taking this course if at least either one of the conditions applies: (1) anyone who took or is taking the courses of Organic Chemistry and Biochemistry; (2) anyone who passed the course of Advanced Chemical Biology I. |
預期每週課後學習時數 |
|
Office Hours |
|
指定閱讀 |
An introduction to Medicinal Chemistry” by Graham L. Patrick (Oxford University Press) |
參考書目 |
(a) “The Organic Chemistry of Drug Design and Drug Action” by Richard
B. Silverman (Elsevier)
(b) “Drug Discovery: A History” by Water Sneader (John Wiley)
(c) “Wilson and Gisvold’s Textbook of Organic Medicinal and
Pharmaceutical Chemistry” 11th Edition, by John H. Block and John M. Beale,
Jr. (Lippincott Williams & Wilkins)
|
評量方式 (僅供參考) |
No. |
項目 |
百分比 |
說明 |
1. |
Oral presentation |
50% |
All the students will be grouped into 7-8 groups. Each group will be assigned 1-2 papers for oral presentation (45 min power-point presentation). |
2. |
Written exams |
50% |
Evaluation will be based on students’ understanding of provided knowledge and materials |
|
週次 |
日期 |
單元主題 |
第1週 |
9/14 |
General aspect I |
第2週 |
9/21 |
Antibiotics and antibiotic resistance I |
第3週 |
9/28 |
陳玉如老師 |
第4週 |
10/05 |
General Aspect II |
第5週 |
10/12 |
Antibiotics and antibiotic resistance II |
第6週 |
10/19 |
Aspirins and nonsteroidal anti-inflammatory agents (NSAIDs) |
第7週 |
10/26 |
Tyrosine kinase inhibitors as effective anti-cancer therapy |
第8週 |
11/02 |
1. 分組報告的papers.
2. Tyrosine kinase inhibitors |
第9週 |
11/09 |
Midterm exam |
第10週 |
11/16 |
Hormone analogues as contraceptives and antiulcer agents |
第12週 |
11/30 |
Targeting proteases: success, failures and future prospects |
第14週 |
12/14 |
Protein drugs |
第16週 |
12/28 |
Student presentations |
第18週 |
1/11 |
Final exam |