1.General aspects: Provide basic terminology and concept, including optimization of lead compounds, structure–activity relationship, oral bioavailability, and pharmacokinetics
2.Antibiotics and antibiotic resistance: Describe the discovery of penicillins and our long-standing battles against bacteria
3.Aspirins and nonsteroidal anti-inflammatory agents (NSAIDs): What happens about the sour success of selective COX-2 inhibitors?
4.Tyrosine kinase inhibitors as effective anti-cancer therapy: There are 518 kinases encoded in the human genome. Specific kinases are targeted for therapeutic development. Some of the examples and the strategies will be reviewed.
5.Hormone analogues as contraceptives and antiulcer agents : Describe the mode of action of histamine receptor antagonists (ranitidine).
6.Targeting proteases: success, failures and future prospects: Historic review of ACE inhibitors (for the treatment of hypertension) and HIV protease inhibitors (for that of AIDS)
7.Protein drugs: Most of protein drugs are glycoproteins. Why are glycosylations so important?