課程名稱 |
蛋白質與胜化學 Protein and Peptide Chemistry |
開課學期 |
108-1 |
授課對象 |
理學院 化學系 |
授課教師 |
陳 平 |
課號 |
Chem5062 |
課程識別碼 |
223 U2690 |
班次 |
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學分 |
3.0 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期二3,4,5(10:20~13:10) |
上課地點 |
化121 |
備註 |
本課程中文授課,使用英文教科書。 限學士班三年級以上 且 限本系所學生(含輔系、雙修生) 總人數上限:60人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1081Chem5062_1 |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
The class will discuss various topics on protein and peptide chemistry such as solid phase peptide synthesis, protein structure and design, and bioactive peptides. Basic understanding of proteins will be provided as a foundation, followed by a discussion of recent papers focusing on the structure, function, and design aspects. |
課程目標 |
The class will discuss various topics on protein and peptide chemistry such as solid phase peptide synthesis, protein structure and design, and bioactive peptides. Basic understanding of proteins will be provided as a foundation, followed by a discussion of recent papers focusing on the structure, function, and design aspects. |
課程要求 |
Students should be registered and should attend all classes. All students (including auditing students) should read the assigned reading material in advance to participate in the discussion of the material during class. |
預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
待補 |
參考書目 |
待補 |
評量方式 (僅供參考) |
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週次 |
日期 |
單元主題 |
第2週 |
9/17 |
Helix Propensity:
Macromolecules 1984, 17, 148 P黃正心, Q周以琳;
Science 1990, 250, 669 P蔡佩璇, Q逄錦穆;
Science 1990, 250, 646 P Ushashi Bhattacharya, Q彭瑋暄;
J. Mol. Biol. 1992, 227, 560 P李華芸, Q黃正心;
Science 1993, 260, 1637 P張景淵, Q蔡佩璇;
Protein Sci. 1994, 3, 843 P莊鈞程, Q Ushashi Bhattacharya;
Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 2833 P林逸婷, Q李華芸
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第3週 |
9/24 |
Midterm |
第4週 |
10/01 |
Origin of Helix Propensity:
Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 5937 P周以琳, Q張景淵;
J. Mol. Biol. 1995, 252, 351 P逄錦穆, Q莊鈞程;
Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 4025 P彭瑋暄, Q林逸婷;
J. Mol. Biol. 1998, 278, 279 P黃正心, Q周以琳;
Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 4930 P蔡佩璇, Q逄錦穆;
Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 10786 P張景淵, Q彭瑋暄;
J. Am. Chem. Soc. 2006, 128, 8227 P莊鈞程, Q黃正心
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第5週 |
10/08 |
Science 1991, 254, 539 P林逸婷, Q 蔡佩璇;
Science 1993, 259, 1288 P周以琳, Q 張景淵;
Science 1993, 262, 1401 P逄錦穆, Q 莊鈞程;
Nature 1994, 371, 80 P彭瑋暄, Q 林逸婷;
Biochemistry 1998, 37, 12603 P黃正心, Q周以琳 ;
Biochemistry 2001, 40, 6352 P蔡佩璇, Q 逄錦穆;
Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 16156 P張景淵, Q 彭瑋暄;
Structure 2006, 14, 247 P莊鈞程, Q黃正心 ;
J. Mol. Biol. 2006, 361, 168 P林逸婷, Q 蔡佩璇
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第6週 |
10/15 |
Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 15457 P周以琳, Q 張景淵;
J. Am. Chem. Soc. 2010, 132, 7586 P逄錦穆, Q 莊鈞程;
Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 530 P彭瑋暄, Q 林逸婷;
J. Am. Chem. Soc. 2012, 134, 2626 P黃正心, Q周以琳 ;
Nature 2009, 458, 859 P蔡佩璇, Q 逄錦穆;
J. Am. Chem. Soc. 2010, 132, 6025 P張景淵, Q 彭瑋暄;
Science 2011, 332, 1071 P莊鈞程, Q黃正心 ;
Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 9151 P林逸婷, Q 蔡佩璇;
Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 14751 P周以琳, Q 張景淵
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第9週 |
11/05 |
Science 2014, 346, 485 P逄錦穆, Q 莊鈞程;
Nat. Commun. 2018, 9, 4132 P彭瑋暄, Q 林逸婷;
ACS Synth. Biol. 2018, 7, 1808 P黃正心, Q周以琳 ;
J. Am. Chem. Soc. 2019, 141, 8787 P蔡佩璇, Q 逄錦穆;
Science 2013, 340, 595 P張景淵, Q 彭瑋暄;
Nano Lett. 2018, 18, 5933 P莊鈞程, Q黃正心 ;
Adv. Funct. Mater. 2019, 1807357 P林逸婷, Q 蔡佩璇;
Sci. Rep. 2017, 7, 10577 P周以琳, Q 張景淵
Angew. Chem. Int. Ed. 2005, 44, 6525 P逄錦穆, Q 莊鈞程;
Chem. Sci. 2018, 9, 7656 P彭瑋暄, Q 林逸婷;
Proc. Natl. Acad. Sci. U.S.A. 2018, 115, E886 P黃正心, Q周以琳 ;
Proc. Natl. Acad. Sci. U.S.A. 2018, 115, E10342 P蔡佩璇, Q 逄錦穆
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第11週 |
11/19 |
Nature 1993, 362, 267 P張景淵, Q 彭瑋暄;
Nature 1994, 367, 660 P莊鈞程, Q黃正心 ;
Biochemistry 1994, 33, 5510 P林逸婷, Q 蔡佩璇;
Nature 1994, 371, 264 P周以琳, Q 張景淵;
Science 1995, 270, 980 P逄錦穆, Q 莊鈞程;
Proteins 1994, 20, 301 P彭瑋暄, Q 林逸婷;
Proteins 1995, 22, 119 P黃正心, Q周以琳 ;
Proteins 1998, 32, 175 P蔡佩璇, Q 逄錦穆;
J. Mol. Biol. 2002, 322, 179 P張景淵, Q 彭瑋暄
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第12週 |
11/26 |
Proteins 1994, 18, 262 P莊鈞程, Q黃正心 ;
Biochemistry 1995, 34, 5718 P林逸婷, Q 蔡佩璇;
J. Mol. Biol. 1995, 252, 366 P周以琳, Q 張景淵;
Proc. Natl. Acad. Sci. USA 1999, 96, 9074 P逄錦穆, Q 莊鈞程;
Proc. Natl. Acad. Sci. USA 1999, 96, 12524 P彭瑋暄, Q 林逸婷;
Proc. Natl. Acad. Sci. USA 2002, 99, 1309 P黃正心, Q周以琳
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第14週 |
12/10 |
Final |
第15週 |
12/17 |
Science 1995, 270, 980 P蔡佩璇, Q 彭瑋暄;
Proc. Natl. Acad. Sci. USA 1999, 96, 9074 P張景淵, Q黃正心 ;
Biopolymers 1968, 6, 1425 P莊鈞程, Q 蔡佩璇;
Biochim. Biophys. Acta 1973, 303, 211 P林逸婷, Q 張景淵;
J. Mol. Biol. 1977, 115, 135 P周以琳, Q 莊鈞程;
Nature 1985, 316, 170 P彭瑋暄, Q 林逸婷;
J. Mol. Biol. 1988, 203, 221 P黃正心, Q周以琳;
J. Mol. Biol. 1989, 206, 759 P蔡佩璇, Q 彭瑋暄;
Protein Engin. 1990, 3, 479 P張景淵, Q黃正心 ;
J. Mol. Biol. 1994, 238, 733 P莊鈞程, Q 蔡佩璇;
Protein Sci. 1994, 3, 2207 P林逸婷, Q 張景淵;
Proc. Natl. Acad. Sci. USA 1995, 92, 97 P周以琳, Q 莊鈞程;
J. Am. Chem. Soc. 1997, 119, 2295 P彭瑋暄, Q 林逸婷;
Science 2011, 331, 571 P黃正心, Q周以琳;
Proc. Natl. Acad. Sci. USA 2011, 108, 14127 P蔡佩璇, Q 彭瑋暄;
Org. Lett. 2012, 14, 732 P張景淵, Q黃正心 ;
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