Course Information
Course title
訊息傳遞與疾病
Signal Transduction in Diseases 
Semester
109-2 
Designated for
VARIOUS PROGRAM  TEACHING PROGRAMME OF STEM CELL AND REGENERATIVE BIO-MEDICINE  
Instructor
陳青周 
Curriculum Number
md&ph5040 
Curriculum Identity Number
420 U4400 
Class
 
Credits
2.0 
Full/Half
Yr.
Half 
Required/
Elective
Elective 
Time
Friday 8,9(15:30~17:20) 
Room
基醫104 
Remarks
本課程中文授課,使用英文教科書。醫學校區研究所共同課程。與李明學、蔡丰喬、徐立中、李建國合授
The upper limit of the number of students: 120. 
Ceiba Web Server
http://ceiba.ntu.edu.tw/1092md_ph5040_ 
Course introduction video
 
Table of Core Capabilities and Curriculum Planning
Association has not been established
Course Syllabus
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Course Description

訊息傳遞與疾病 

Course Objective
待補 
Course Requirement
待補 
Student Workload (expected study time outside of class per week)
 
Office Hours
 
Designated reading
待補 
References
1. Biochemistry of signal transduction and regulation / Gerhard Krauss.
Weinheim : Wiley-VCH Verlag GmbH & Co. KGaA, 2008. 4th
2. Signal transduction / Bastien D. Gomperts, Ijsbrand M. Kramer, Peter E.R.
Tatham. Amsterdam ; Boston ; London : Elsevier/Academic Press, c2009. 2nd ed 
Grading
   
Progress
Week
Date
Topic
第1週
2/26  Introduction: Basics of cell signaling 
第2週
3/05  G-protein coupled signal transmission pathways 
第3週
3/12  Intracellular messenger substances: “Second messengers” 
第4週
3/19  Transmembrane receptors with tyrosine kinase activity 
第5週
3/26  Signal transmission via Ras proteins 
第6週
4/02  停課一週 
第7週
4/09  Protein cascades of the Mitogen-activated protein kinase pathway 
第8週
4/16  Signaling to NF-κB: regulation by ubiquitination 
第9週
4/23  Midterm Exam期中考 (範圍:2/26-4/16授課內容) 
第10週
4/30  Signaling in immune system: Innate immunity 
第11週
5/07  Signaling in immune system: TCRs and BCRs 
第12週
5/14  Apoptosis 
第13週
5/21  Non-apoptotic cell death 
第14週
5/28  Epigenetic mechanisms 
第15週
6/04  Ca2+ signalling and Ca2+-dependent adhesions 
第16週
6/11  Targeting transduction pathways for research and medical intervention 
第17週
6/18  Final Exam期末考 (期末作業通知放在檔案也有另外寄信通知)