423 M1470 Advanced Medicinal Chemistry I (高等藥物化學 (一))必修
Prerequisites: None
Terms: Fall
Credits: 2
Format: Lecture
Instructors: J.-W. Chern, J.-H. Guh, F.-L. Kung, L.-W. Hsin, and J.-H. Lin

Course Description: This is the first part of a one-year survey course aimed to introduce first-year medicinal chemistry graduate students to various aspects of drug design and development. The course will begin with a general introduction to the drug development process and cover macromolecular drug targets and lead identification/optimization. Students who are interested in a particular subject may elect a more advanced course in consultation with their advisor. Two hours of lecture per week.

Week Topic
1 Past Approaches to Discovering New Drugs as Medicines; General Aspects of Medicinal Chemistry (JWC)
Drug Targets
2 Receptor (JHG)
3 Receptor (JHG)
4 Ion Channels (JHG)
5 Neurotransmitters (JHG)
6 Protein Structure and Function (FLK)
7 Characterization of Enzymes (FLK)
8 DNA (FLK)
Principles of Drug Design
9 Bioisosteres, Conformatinoal Restriction and Prodrugs I: Approaches to Lead Optimization (JWC)
10 Bioisosteres, Conformatinoal Restriction and Prodrugs II: Approaches to Lead Optimization (JWC)
11 Primary Exploration of Structure-Activity Relationship I: Molecular Variations in Homologues Series (JWC)
12 Primary Exploration of Structure-Activity Relationship II: Ring Transformation (JWC)
13 QSAR (LWH)
14 Pharmacophore Identification and Receptor Mapping (JHL)
15 Protein Homology Modeling and Drug Discovery (JHL)
16 Design of Peptidomimetics I (LWH)
17 Design of Peptidomimetics II (LWH)