These lectures are aimed to present a brief introduction of nomenclature and physical chemical properties of heterocycles. The lectures will give basic knowledge of particular heterocycles which allow the students to be able to rationalize the relationship between biological activity and heterocyclic medicinal agents..


Time：Wednesday, 8:00-10:00
Place：1234
Instructor：Ji-Wang Chern

1. 2/18 Introduction to heterocycles
2. 2/25 Structures and main physical properties of aromatic heterocycles
3. 3/3 Reactivity of aromatic heterocycles
4. 3/10 Synthesis of aromatic heterocycles
5. 3/17 Typical reactivity, reaction and synthesis of pyrroles
6. 3/24 Typical reactivity, reaction and synthesis of thiophenes and furans
7. 3/31 1,2-Azoles: pyrazoles, isothiazoles and isoxazoles: reactions and synthesis
8. 4/7 1,3-Azoles:imidazoles, thiazoles and oxazoles: reactions and synthesis
Examination I
9. 4/14 Five-membered rings containing more than two hetero atoms
10. 4/21 Indoles: reactions and synthesis
11. 4/28 Chemical reactivity, reactions and synthesis of benzothiophenes and benzofurans
12. 5/5 Chemical reactivity, reactions and synthesis of pyridines
13. 5/12 Chemical reactivity, reactions and synthesis of quinolines and isoquinolines
14. 5/19 Six-membered rings containing more than two hetero atoms
15. 5/26 Heterocycles as a synthon in the organic synthesis
16. 6/2 Examination II

References：
1. Heterocyclic Chemistry, third edition, by J. A. Joule, K. Mills, and G. F. Smith, Chapman ＆ Hall.
2. Heterocyclic Chemistry, third edition, by Thomas L. Gilchrist, Longman.
3. Comprehensive Heterocyclic Chemistry, Vol. 1-11, edited by A. R. Katritzky, C. W. Rees and E. F. V. Scriven, Pergamon.
4. Progress in Heterocyclic Chemistry, Vol. 1-13, published by International Society of Heterocyclic Chemistry, Pergamon.
5. Aromatic Heterocyclic Chemistry, D. T. Davies, Oxford Scientific Publications.