課程資訊
課程名稱
血液凝固學特論
Special Topics in Haemostasis and Thrombosis 
開課學期
103-1 
授課對象
醫學院  醫學檢驗暨生物技術學研究所  
授課教師
林淑華 
課號
CliLab8005 
課程識別碼
424 D4000 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期一3,4(10:20~12:10) 
上課地點
 
備註
上課教室:檢驗大樓511室
總人數上限:20人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1031CliLab8005_ 
課程簡介影片
 
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課程概述

血液凝固學與血栓及心血管疾病有密切關係,此領域進展神速。本課程以討論方式,指導博士班學生針對上述內容包括基礎學理與最近進展的知識作深入的探討。 

課程目標
待補 
課程要求
待補 
預期每週課後學習時數
 
Office Hours
 
指定閱讀
J Haemostasis and Thrombosis (2014), Jan~Dec. issues 
參考書目
待補 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第2週
9/23  Inhibitors – cellular aspects and novel approaches for tolerance
Rituximab as first-line treatment for the management of adult patients with non-severe hemophilia A and inhibitors
 
第4週
10/07  Epidemiological aspects of inhibitor development redefine the clinical importance of inhibitors
Inhibitors – genetic and environmental factors
Antiplatelet therapy: new pharmacological agents and changing paradigms
 
第6週
10/21  Haemophilia care – beyond the treatment guidelines
Current status of haemophilia gene therapy
 
第8週
11/04  Rare bleeding disorders – bleeding assessment tools, laboratory aspects and phenotype and therapy of FXI deficiency
Mechanisms underlying platelet function defect in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia: potential role for candidate RUNX1 targets
Energy and motion: AMP-activated protein kinase α1 and its role in platelet activation
The Ca2+/calmodulin-dependent kinase kinase β-AMP-activated protein kinase-α1 pathway regulates phosphorylation of cytoskeletal targets in thrombin-stimulated human platelets
 
第10週
11/18  Genomics of bleeding disorders
Genetic testing in bleeding disorders
 
第12週
12/02  Primary haemostasis: newer insights
Novel products for haemostasis – current status
With blood in the joint – what happens next? Could activation of a pro-inflammatory signalling axis leading to iRhom2/TNFα-convertase-dependent release of TNFα contribute to haemophilic arthropathy?
Oral gene therapy for hemophilia B using chitosan-formulated FIX mutants
 
第14週
12/16  Monitoring of modified factor VIII and IX products
Amplification of human platelet activation by surface pannexin-1 channels
Laboratory testing for factor inhibitors
Changing paradigm of prophylaxis with longer acting factor concentrates
 
第16週
12/30  von Willebrand disease and platelet disorders
Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets
Novel products for haemostasis
Prophylaxis in real life scenarios