課程資訊
課程名稱
量性研究方法論
Quantitative Research Methodology 
開課學期
106-1 
授課對象
醫學院  護理學研究所  
授課教師
孫秀卿 
課號
NURSE8028 
課程識別碼
426ED4420 
班次
 
學分
2.0 
全/半年
半年 
必/選修
必修 
上課時間
星期一6,7(13:20~15:10) 
上課地點
護討論室1 
備註
本課程以英語授課。與陳佳慧、賴裕和合授
限博士班
總人數上限:20人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1061NURSE8028_QRM 
課程簡介影片
 
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課程概述

Course Description:
This class is to prepare doctoral students to develop advanced knowledge, logical thinking and practical abilities in designing, conducting and implementing quantitative research. Students are expected to train themselves through massive reading, interactive discussion, original research paper critique and research project design and presentation. Knowledge and skills related to quantitative research, including measurements, data collection and scientific writing, etc. will be discussed in this class. Critical and logical thinking and problem-solving abilities in developing quantitative research are expected after finishing this class.
 

課程目標
Course Objectives:
At completion of the course, the students are prepared to:
1. Demonstrate knowledge of various designs and methods in quantitative research.
2. Identify methodological issues pertinent to quantitative research.
3. Demonstrate the skills in data collection, analysis, and reporting techniques in
quantitative research.
4. Apply principles of instrument development to current measurement problems.
5. Evaluate the quality and relevance of quantitative research.
 
課程要求
待補 
預期每週課後學習時數
 
Office Hours
 
指定閱讀
待補 
參考書目
Textbooks and Selective Classical References:
Jadad, A. R., & Enkin, M. W. (2007). Randomized controlled trials: Questions, answers, and musings (2nd ed.). Oxford: Blackwell Publishing.
Behling, O., & Law, K. S. (2000). Translating questionnaires and other research instruments: Problems and solutions. Thousand Oaks, CA: Sage.
Brink, P. J., & Wood, M. J. (1998). Advanced design in nursing research (2nd ed.). Thousand Oaks, CA: Sage
Burns, N. & Grove, S. K. (2013). The practice of nursing research: Appraisal, synthesis, and generation of evidence (7th ed.). Philadelphia, PA: W.B. Saunders.
Menard, S. W. (2002). Longitudinal research (2 nd ed.). Thousand Oaks, CA: Sage.
Polit, D. F., & Beck, C. T. (2011). Nursing Research: Generating and assessing evidence for nursing practice (9th ed.). Philadelphia: Lippincott William & Wilkins.
Sidani, S., & Braden, C. J. (1998). Outcomes-related factor. In Souraya Sidani (Ed.), Evaluating nursing interventions: A theory driven approach (pp. 138-160). Thousand Oaks, CA: Sage.
Streiner, D. L., & Norman, G. R. (2008). Health measurement scales: A practical guide to their development and use. (4 th ed.). Oxford: Oxford Medical Publications.
Vogt, W. P. (2011). Dictionary of statistics and methodology: a nontechnical guide for the social science (4 th ed.). Thousand Oaks, CA: Sage.
Waltz, C. F., Strickland, O. L., & Lenz, E. R. (2010). Measurement in nursing and health research (4 rd ed.). New York: Springer.
台灣護理學會編譯•(2003)•科學誠正指引第二版•台北:台灣護理學會。
國家衛生研究院論壇生命暨醫療倫理委員會•(2004)•知情同意:常見問答集Q & A•台北:國家衛生研究院。

Linkage from Theory to Research and Practice:
Avant, K. C. (1991). The theory-research dialectic: A different approach. Nursing Science Quarterly, 4(1), 2.
Benner, P. (2000). Links between philosophy, theory, practice, and research. Canadian Journal of Nursing Research, 32(2), 7-13.
Burns, N. & Grove, S. K. (2008). The practice of nursing research: Appraisal, Synthesis, and Generation of Evidence (6th ed.). Philadelphia, PA: W.B. Saunders.
Chen, C. C-H. (2005). A framework for studying the nutritional health of community-dwelling elders. Nursing Research, 54, 13-21.
Dulock, H. L., & Holzemer, W. L. (1991). Substruction: Improving the linkage from theory to method. Nursing Science Quarterly, 4(2), 83-87.
McQuiston, C. M., & Campbell, J. C. (1997). Theoretical substruction: A guide for theory testing research. Nursing Science Quarterly, 10(3), 117-123.
Radwin, L., & Fawcett, J. (2002). A conceptual model-based programme of nursing research: Retrospective and prospective applications. Journal of Advanced Nursing, 40, 355-360.
Im, E. O., & Chang, S. J. (2012). Current trends in nursing theories. Journal of Nursing Scholarship, 44(2), 156-164.

Experimental & Quasi-Experimental Designs:
Bench, S., Day, T., & Metcalfe, A. (2013). Randomised controlled trials: an introduction for nurse researchers. Nurse Researcher, 20(5), 38-44.
Brown, S. J. (2002). Nursing intervention studies: A descriptive analysis of issues important to clinicians. Research in Nursing & Health, 25(4), 317-327.
Conn, V. S., Rantz, M. J., Wipke-Tevis, D. D., & Maas, M. L. (2001). Designing effective
nursing interventions. Research in Nursing & Health, 24(5), 433-442.
Downs, S.H., & Black, N. (1998). The feasibility of creating a checklist for the assessment of
the methodological quality both of randomized and non-randomized studies of health care interventions. Journal of Epidemiology and Community Health, 52, 377-384.
Fogg, L., & Gross, D. (2000). Threats to validity in randomized clinical trials. Research in Nursing & Health, 23(1), 79-87.
Gross, D, & Fogg, L. (2001). Clinical trials in the 21st century: The case for participant-centered research. Research in Nursing & Health, 24, 530-539.
Lindsay, B. (2004). Randomized controlled trials of socially complex nursing interventions: Creating bias and unreliability. Journal of Advanced Nursing, 45(1), 84-94.
Polit, D. F., Gillespie, & B. M. (2010). Intention-to-treat in randomized controlled trials: recommendations for a total trial strategy. Research in Nursing & Health, 33(4), 355-368.
Schumacher, K. L., Koresawa, S., West, C., Dodd, M., Paul, S. M., Tripathy, D., et al. (2005). Qualitative research contribution to a randomized clinical trial. Research in Nursing & Health, 28, 268-280.
Siebens, H., Aronow, H., Edwards, D., & Gbasemi, Z. (2000). A randomized controlled trial of exercise to improve outcomes of acute hospitalization in older adults. Journal of the American Geriatric Society, 48, 1545-1552.

Outcome Research:
Blackwood, B., Marshall, J., & Rose, L. (2015). Progress on core outcome sets for critical care research. Current Opinion in Critical Care, 21(5), 439-444. doi: 10.1097/mcc.0000000000000232
Ingersoll, G. L., McIntosh, E., & Williams, M. (2000). Nurse-sensitive outcomes of advanced practice. Journal of Advanced Nursing, 32(5), 1272-1281.
Jefford, M., Stockler, M. R., & Tattersall, M. H. (2003). Outcomes research: what is it and why does it matter? Internal Medicine Journal, 33(3), 110-118.
Lake, E. T. (2006a). Multilevel models in health outcomes research. Part I: Theory, design, and measurement. Applied Nursing Research, 19(1), 51-53. doi: 10.1016/j.apnr.2005.10.002
Lake, E. T. (2006b). Multilevel models in health outcomes research. Part II: statistical and analytic issues. Applied Nursing Research, 19(2), 113-115. doi: 10.1016/j.apnr.2006.01.001
Sales, A. E. (2007). A view from health services research and outcomes measurement. Nursing Research, 56(4 Suppl), S67-71. doi: 10.1097/01.NNR.0000280632.86525.8f
Windle, P. E. (2005). Outcomes research: a paradigm shift for nursing research. Journal of Perianesthesia Nursing, 20(5), 351-353. doi: 10.1016/j.jopan.2005.08.007
Zhang, A. Y., & Fu, A. Z. (2016). Cost-effectiveness of a behavioral intervention for persistent urinary incontinence in prostate cancer patients. Psychooncology, 25(4), 421-427. doi: 10.1002/pon.3849

Issues in Quantitative Design and Measurement:
Azuero, A., Pisu, M., McNees, P., Burkhardt, J., Benz, R., & Meneses, K. (2010). An
application of longitudinal analysis with skewed outcomes. Nursing Research, 59, 301-307.
Banerjee, M., & Fielding, J. (1997). Interpreting Kappa values for two-observer nursing
diagnosis data. Research in Nursing & Health, 20, 465-470.
Bernal, H., Wooley, S., & Schensul, J. J. (1997). The challenge of using Likert-type scales with low-literate ethnic population. Nursing Research, 46(3), 179-181.
Goodwin, L. D. (1996). Determining cut-off scores. Research in Nursing & Health, 19, 249-256.
Goodwin, L. D., & Goodwin, W. L. (1991). Estimating construct validity. Research in
Nursing & Health, 14, 235-243.
Hinds, P. S., Schum, L. & Srivastava, D. K. (2002). Is clinical relevance sometimes lost in
summative scores. Western Journal of Nursing Research, 24, 345-353.
Higgins, P. A., & Daly, B. J. (1999). Research methodology issues related to interviewing the
mechanically ventilated patient. Western Journal of Nursing Research, 21, 773-784.
Hulley, S. B., Cummings, S. R., & Bowner, W. S. (2001). Implementing the study: Pretesting,
quality control, and protocol revisions. Designing Clinical Research. (2nd ed.). Philadelphia: Lippincott Williams & Wilkins, 259-273. (e-book, 2007)
Hughes, L. C., & Preski, S. (1997). Using key informant methods in organizational survey research: Assessing for informant bias. Research in Nursing & Health, 20, 81-92.
Jones, E. G., & Kay, M. (1992). Instrumentation in cross-cultural research. Nursing Research,
41(3), 186-188.
King, K. M. (2003). Is there a “representative” sample? Western Journal of Nursing Research, 25(1), 5-7.
Knapp, T. R., & Brown, J. K. (1995). Ten measurement commandments that often should be broken. Research in Nursing & Health, 18, 465-469.
Knapp, T. R. (1991). Coefficient alpha: Conceptualizations and anomalies. Research in Nursing & Health, 14, 457-460.
Kneipp, S. M., & Yarandi, H. N. (2002). Complex sampling designs and statistical issues in
secondary analysis. Western Journal of Nursing Research, 24(5), 552-566.
Krause, M. R., Serlin, R. C., Ward, S. E., Rony, Y. Z, Ezenwa, M. O., & Naab, F. (2010).
Testing Mediation in Nursing Research: Beyond Baron and Kenny. Nursing Research, 59, 288-294
Lee, J. W., Jones, P. S., Mineyama, Y., & Zhang, X. E. (2002). Cultural differences in responses to a Likert scale. Research in Nursing & Health, 25(1), 295-306.
Lobo, M. L. (1993). Code books: A critical link in the research process. Western Journal of Nursing Research, 15(3), 377-385.
Lorig, K., Gonzalez, V. M., Ritter, P., & Brey, V. N. D. (1997). Comparison of three methods of data collection in an urban Spanish-speaking population. Nursing Research, 46(6), 230-234.
Lynn, M. R. (1986). Determination and quantification of content validity. Nursing Research, 35(6), 382-385.
McKinley, S., Coote, K., & Stein-Parbury, J. (2003). Development and testing of a face scale for the assessment of anxiety in critically ill patients. Journal of Advanced Nursing, 41(1), 73-99.
Patrician, P. A. (2002). Multiple imputation for missing data. Research in Nursing & Health, 25 (1), 76-84.
Phillips, L. R., de Hernandez, I. L., & de Ardon, E. T. (1994). Focus on psychometrics: Strategies for achieving cultural equivalence. Research in Nursing & Health, 17, 149-154.
Polit, D. F., & Beck, C. T. (2010). Generalization in quantitative and qualitative research: Myths and strategies. International Journal of Nursing Studies, 47, 1451-1458.
Stewart, B. J., & Archbold, P. G. (1992). Nursing intervention studies require outcome measures that are sensitive to change: Part one: Research in Nursing & Health, 15, 477-481.
Stewart, B. J., & Archbold, P. G. (1993). Nursing intervention studies require outcome measures that are sensitive to change: Part two: Research in Nursing & Health, 16, 77-81.
Weinstein, J. N., & Deyo, R. A. (2000). Clinical research issues in data collection. Spine, 25(24), 3104-3109.
Wynd, C. A., Schmidt, B., & Schaefer, M. A. (2003). Two quantitative approaches for estimating content validity. Western Journal of Nursing Research, 25(5), 508-518.
Youngblut, J. M., & Casper, G. R. (1993). Single-item indications in nursing research. Research in Nursing & Health, 16, 459-465.
林正祥•(1994)•研究設計之樣本數決定•中華民國公共衛生學會雜誌,12(3) ,282-290。
盧成皆•(1996)•護理研究中常遇到的統計問題實例探討•護理研究,4(3) ,298-306。
盧成皆•(1997)•線性複迴歸所需樣本數目之討論•護理研究,5(4),377-383。
盧成皆、林京芬(1998)•關於Cronbach's Alpha 的使用與闡釋•護理研究,6(1),82-88。

Instrument Translation and Testing:
Chang, A. M., Chau, J. P. C., & Holroyd, E. (1999). Translation of questionnaires and issues of equivalence. Journal of Advanced Nursing, 29, 316-322.
DeVellis, F. R. (2012). Scale development : Theory and applications (3rd Ed). Thousand Oaks.Sage, Carlifornia
Yu, D. S. F., Lee, D. T. F., & Woo, J. (2004). Issues and challenges of instrument translation. Western Journal of Nursing Research, 26, 307-320.
葉美玲、陳興夏•(1998)•測量工具翻譯與效度•長庚護理, 9(1), 64-68。

Academic Writing:
Becker, P. T. (2004). What happens to my manuscript when I send it to Research in Nursing & Health. Research in Nursing & Health, 27, 379-381.
Broome, M. E. (2003). Scientific integrity: The cornerstone of knowledge. Journal of Neuroscience Nursing, 35(1), 56-59.
Dallas, C. M., Norr, K., Dancy, B. L., Kavanaugh, K., & Cassata, L. (2005). An example of a successful research proposal: Part I. Western Journal of Nursing Research, 27(1), 50-72.
Dallas, C. M., Norr, K., Dancy, B. L., Kavanaugh, K., & Cassata, L. (2005). An example of a successful research proposal: Part II. Western Journal of Nursing Research, 27(2), 210-231.
Froman, R. D. (2004). Numbers, numbers everywhere. Research in Nursing & Health, 27, 145-147.
Higdon, J. & Topp, R. (2004). How to develop a budget for a research proposal. Western Journal of Nursing Research, 26, 922-929.
Locher, J. L., Robinson, C. O., Roth, D. L., Ritchie, C. S., & Burgio, K. L. The effect of presence of others on caloric intake in homebound older adults. Journal of Gerontology: Medical Sciences, 60A, 1475-1478.
Lusk, S. L. (2004). Developing an outstanding grant application. Western Journal of Nursing Research, 26, 367-373.
Ness, V., Duffy, K., McCallum, J., & Price, L. (2014). Getting published: Reflections of a collaborative writing group. Nurse Education Today, 34(1), 1-5.
Owen, S. V. (2005). The significance of significance. Research in Nursing & Health, 28, 281-282.
洪祖培、陳錦得•(1999)•醫學論文的列名準則與責任•台灣醫學,3(5), 543-549。
 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
Class participation 
15% 
 
2. 
Article critique (due one week after presentation)  
25% 
 
3. 
Oral presentation for 3 selected topics 
40% 
 
4. 
Final paper (due Jan. 16, 2017) 
20% 
 
 
課程進度
週次
日期
單元主題
第1週
9/11  Course Overview & Group Introduction 
第2週
9/18  Linkage Among Theory, Research & Practice 
第3週
9/25  Survey Design – Cross-sectional Design  
第4週
10/02  Longitudinal Design 
第5週
10/09  Holiday 
第6週
10/16  Designing Intervention Studies  
第7週
10/23  Assessing Quality of Intervention Research  
第8週
10/30  Outcome research  
第9週
11/06  Measurement Theory: Reliability & Validity 
第10週
11/13  Measuring Bio-Indicators in Nursing Research 
第11週
11/20  Instrument Development & Translation 
第12週
11/27  Sampling & Sample Size 
第13週
12/04  Academic Writing 
第14週
12/11  Article Critique Presentation (I)  
第15週
12/18  Article Critique Presentation (II) 
第16週
12/25  Final Presentation (I) 
第17週
1/01  Holiday 
第18週
1/08  Final Presentation (II) & Course Evaluation