課程資訊
課程名稱
腸胃道生理學特論
Gastrointestinal Physiology 
開課學期
100-2 
授課對象
醫學院  生理學研究所  
授課教師
余佳慧 
課號
Physio7019 
課程識別碼
441EM2800 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期三3,4(10:20~12:10) 
上課地點
基醫1003 
備註
本課程以英語授課。
總人數上限:25人
外系人數限制:10人 
 
課程簡介影片
 
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課程概述

This course is intended for further in-depth study of the gastrointestinal physiology and immunology. Functions of the gastrointestinal tract include motility, digestion, absorption, secretion and barrier. The GI tract plays dual roles, one serving as the first line for nutrient uptake and the other as a defense system against microbial pathogens. The gastrointestinal tract is the largest reservoir of commensal bacteria in the human body, providing nutrient and space for the survival of microbes while concurrently operating mucosal barriers to confine and restrict the microbial population. The turnover rate of intestinal epithelial cells along the crypt/villus axis that involves processes of proliferation, differentiation, apoptosis and shedding is crucial for maintenance of gut homeostasis. Recent scientific studies suggest dynamic interaction among enteric nervous system, immune system and the gastrointestinal mucosa. The lymphoid tissues in the gastrointestinal tract contain the largest number of immune cells in the body, termed gut-associated lymphoid tissue (GALT). The gastrointestinal immunity protects against invasion of potential pathogens, and provides oral tolerance to food proteins without developing an adverse immune response to unharmful dietary particles. The balance between immunity and tolerance in the gut plays a crucial role in the pathogenesis of various gastrointestinal diseases. 

課程目標
The purpose of the course is to give students a broad knowledge of gastrointestinal physiology through lectures and to further their research ability by critical reading and discussion of up-to-date scientific papers in this field. 
課程要求
Undergraduate students over forth year, and graduate students in medicine-and biology-related studies are encouraged to take the course. The course is offered as two credits per school term. 
預期每週課後學習時數
 
Office Hours
 
指定閱讀
 
參考書目
 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
presentations 
60% 
presentations of scientific papers in the field of gastroenterological immunophysiology 
2. 
assay 
30% 
self-pick topics including outlines; 10-page essay double-spaced not including references 
3. 
participation in class 
10% 
questions and answers in the discussion at the end of each presentation 
 
課程進度
週次
日期
單元主題
第1週
2/22  Introduction: Gastrointestinal anatomy and histology 
第2週
2/29  Digestion and absorption: Brush border enzymes and Nutrient transporters 
第3週
3/07  Anion secretion: chloride and bicarbonate ions 
第4週
3/14  Motility and neural regulation, brain-gut axis 
第5週
3/21  Chemical barrier function: defensin and cathelicidin 
第6週
3/28  Physical barrier function: tight junctions and epithelial permeability 
第7週
4/04  Crypt-villus axis 
第8週
4/11  Epithelial cell apoptosis and carcinogenesis 
第9週
4/18  Stem cell proliferation in gut 
第10週
4/25  Conferences 
第11週
5/02  Commensal bacteria products and energy metabolism 
第12週
5/09  Gut commensal bacteria: gut-brain axis 
第13週
5/16  Antiobiotics and superbug 
第14週
5/23  Intestinal innate immunity, neutrophils and macrophages 
第15週
5/30  Intestinal adaptive immunity and Gut-associated lymphoid tissue 
第16週
6/06  Oral tolerance and Commensal-induction of Treg cells 
第17週
6/13  Balance between Treg cells and Th17 cells 
第18週
6/20  Discussion of essay outline and question formats; review