課程資訊
課程名稱
腸胃道生理學特論
Gastrointestinal Physiology 
開課學期
110-2 
授課對象
醫學院  生理學研究所  
授課教師
余佳慧 
課號
Physio7019 
課程識別碼
441EM2800 
班次
 
學分
2.0 
全/半年
半年 
必/選修
選修 
上課時間
星期三3,4(10:20~12:10) 
上課地點
基醫1003 
備註
本課程以英語授課。
限碩士班以上
總人數上限:20人
外系人數限制:5人 
 
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課程概述

THIS COURSE IS INTENDED FOR FURTHER IN-DEPTH STUDY OF THE GASTROINTESTINAL PHYSIOLOGY. GRADUATE STUDENTS IN MEDICAL-RELATED STUDIES ARE ENCOURAGED TO TAKE THE COURSE. THE COURSE IS OFFERED AS TWO CREDITS PER SCHOOL TERM. THE PHYSIOLOGY OF GASTROINTESTINAL TRACT INCLUDES MOTILITY, DIGESTION, ABSORPTION, SECRETION AND BARRIER FUNCTIONS. THE GASTROINTESTINAL TRACT PLAYS DOUBLE ROLES, SERVING AS THE FIRST LINE FOR NUTRIENT UPTAKE AND DEFENSE SYSTEM AGAINST MICROBIAL PATHOGENS. RECENT SCIENTIFIC STUDIES SUGGEST STRONG INTERACTION AMONG ENTERIC NERVOUS SYSTEM, IMMUNE SYSTEM AND THE GASTROINTESTINAL MUCOSA. THIS COURSE WILL BE IN THE FORMAT OF CRITICAL DISCUSSION OF SCIENTIFIC PAPERS IN THE FIELD OF GASTROINTESTINAL PHYSIOLOGY. 

課程目標
OUTLINES:
1. INTRODUCTION OF GASTROINTESTINAL ANATOMY AND HISTOLOGY

MOTILITY:
2. DIGESTIVE TRACT MOTILITY
3. CONTROL OF MOTILITY: ENTERIC NERVOUS SYSTEM

SECRETION FUNCTION:
4. MALABSORPTIVE DIARRHEA
5. SECRETIVE DIARRHEA

DIGESTION:
6. PANCREATIC ENZYME ACTIVATION
7. EPITHELIAL ENZYME REGULATION

ABSORPTION:
8. GLUCOSE TRANSPORTERS
9. ION TRANSPORTERS

BARRIER FUNCTION:
10. PHYSICAL BARRIER FUNCTION: EPITHELIAL TIGHT JUNCTION
11. CHANGES IN EPITHELIAL PERMEABILITY
12. CHEMICAL BARRIER FUNCTION: DEFENSIN AND CATHELICIDIN

EPITHELIAL CELL PROLIFERATION AND APOPTOSIS
13. CRYPT HYPERPLASIA
14. EPITHELIAL CELL APOPTOSIS AND SLOUGH OFF

INTERACTION BETWEEN IMMUNE SYSTEM, NERVOUS SYSTEM AND EPITHELIAL MUCOSA:
15. MAST CELLS AND EPITHELIAL ION TRANSPORT
16. INTRAEPITHELIAL LYMPHOCYTES
17. ENTERIC NERVOUS TRANSMITTERS AND EFFECT ON EPITHELIAL FUNCTIONS 
課程要求
STUDENTS WILL BE GRADED BY PARTICIPATION IN CLASS (10 %), REPORTS (30 %), AND PRESENTATIONS (60 %). 
預期每週課後學習時數
 
Office Hours
 
指定閱讀
 
參考書目
 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
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