本課程內容以講授最近發展的基因體技術，原理及應用為主，並輔以研讀討論與課程相關的期刊論文。課程內容包括：
Introduction: brief history of genetics
Comparative Gene-Expression Analysis I: Hybridization-based techniques
-- In-house spotted arrays
-- Prespotted array (inkjet print)
-- Photolithograph
-- Maskless array synthesis
-- BeadChip
-- MicroArray Quality Control (MAQC) Project

Comparative Gene-Expression Analysis II: PCR-based techniques
-- RT-PCR

Comparative Gene-Expression Analysis III: Sequence-based techniques
-- Next generation sequencing

Genomic approaches to study:
-- Gene expression profiling
-- Single nucleotide polymorphism (SNP), copy number variation (CNV), loss of heterozygosity (LOH)
-- DNA-protein interaction
-- Epigenomics (DNA Methylation)
-- microRNA