課程資訊
課程名稱
 神經退化研究論著選讀
Neurodegeneration Seminar 
開課學期
 101-2 
授課對象
 醫學院  生理學研究所  
授課教師
 詹智強 
課號
 Physio7040 
課程識別碼
 441 M3900 
班次
  
學分
 2 
全/半年
 半年 
必/選修
 選修 
上課時間
 星期三6,7(13:20~15:10) 
上課地點
 基醫1003 
備註
 本課程中文授課,使用英文教科書。
總人數上限：25人
外系人數限制：15人 
  
課程簡介影片
 
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課程概述

本課程內容以最近5年神經退化研究(Neurodegeneration)相關的期刊論文為主。課程依據下列主題，找尋適當的期刊論文研讀與討論
This course is based on lectures and discussions on recent research in the field of neurodegeneration. Lectures and discussions explore the pathology, molecular mechanisms, and therapeutic aspects of neurodegenerative disorders. Topics include the intracellular mechanisms regulating neuron maintenance, as well as neurodegenerative conditions such as Parkinson's disease, Alzheimer's disease, Peripheral neuropathies, etc. Through literature reading and group discussion, the students should understand the recent discoveries in the field of neurodegeneration. 

課程目標
 The lectures and discussions will focus on recent research (within 5 years) in the field of neurodegeneration. Students will be assigned relevant paper according to the topics listed below for discussion.
1. Introduction: Overview of Neurodegeneration
2. Neurodegenerative Disorders- Molecular Mechanisms
- Genetic Links
- Intracellular Mechanisms: Deranged Calcium Signaling
- Intracellular Mechanisms: Deregulated Protein Degradative Pathways
- Intracellular Mechanisms: Reduced Axonal Transport
3. Programmed Cell Death and Neurodegeneration
- Apoptosis
- Autophagy
4. Intracellular Trafficking and Neurodegeneration
5. Pathology of Neurodegenerative Disorders
6. Therapeutics for Neurodegenerative Disorders 
課程要求
 不遲到早退, 積極參與課堂間的報告與討論
Students are expected to give oral presentations in class based on a selected journal article from the reading list. There is one final exam or oral presentation. Attendance is required at all class meetings. 
預期每週課後學習時數
  
Office Hours
 另約時間 備註： by appointment 
指定閱讀
 Selected papers within 5 years from high-profile journals, with focus on the molecular mechanisms of neurodegeneration 
參考書目
 Selected papers within 5 years from high-profile journals, with focus on the molecular mechanisms of neurodegeneration. 
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 出席及參與度 
20% 
 不遲到早退；積極參與討論 
2. 
 口頭報告 
40% 
 課堂間的報告與討論參與度  
3. 
 期末報告 
40% 
 口頭、書面報告兩部分,各佔20% 
 
課程進度
週次
日期
單元主題
第1週
 2/20  Introduction: Neurodegeneration Overview  
第2週
 2/27  Intracellular Mechanisms of Neurodegeneration (I) – Autophagy 
第3週
 3/06  Intracellular Mechanisms of Neurodegeneration (II) – Ubiquitous Endolysosomal Degradation Pathways  
第4週
 3/13  Intracellular Mechanisms of Neurodegeneration (III) – Neuron-Specific Protein Degradation Pathways 
第5週
 3/20  Intracellular Mechanisms of Neurodegeneration (IV) – Mitochondrial Dysfunction 
第6週
 3/27  Intracellular Mechanisms of Neurodegeneration (V) – Axonal Transport 
第7週
 4/03  Intracellular Mechanisms of Neurodegeneration (VI) – Calcium Signaling 
第8週
 4/10  Intracellular Mechanisms of Neurodegeneration (VIII) – Apoptosis I 
第9週
 4/17  Intracellular Mechanisms of Neurodegeneration (IX) – Apoptosis II 
第10週
 4/24  Intracellular Mechanisms of Neurodegeneration (X) – Cytoplasmic Cell Death 
第11週
 5/01  Molecular Mechanisms of Neurodegeneration: PolyQ Diseases 
第12週
 5/08  Molecular Mechanisms of Neurodegeneration: Alzheimer’s Disease 
第13週
 5/15  Molecular Mechanisms of Neurodegeneration: Tauopathies and FTDP-17 
第14週
 5/22  Molecular Mechanisms of Neurodegeneration: Parkinson’s disease 
第15週
 5/29  Molecular Mechanisms of Neurodegeneration: Peripheral Neuropathies 
第16週
 6/05  Molecular Mechanisms of Neurodegeneration: Lysosomal Storage Diseases 
第17週
 6/12  Therapeutics for Neurodegenerative Disorders