課程資訊
課程名稱
 神經免疫生理學
Neuroimmunophysiology 
開課學期
 108-2 
授課對象
 醫學院  生理學研究所  
授課教師
 張哲逢 
課號
 Physio5005 
課程識別碼
 441 U1800 
班次
  
學分
 2.0 
全/半年
 半年 
必/選修
 選修 
上課時間
 星期二9,10(16:30~18:20) 
上課地點
 基醫1003 
備註
 本課程中文授課,使用英文教科書。
總人數上限：20人 
  
課程簡介影片
 
核心能力關聯
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課程大綱
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課程概述

The traditional view that brain is an immune-privileged area has shifted drastically with the growing understanding that the CNS and immune systems interact on many levels in both health and disease. The goal of this course is to provide specific knowledge of immunology in the brain and in immune-mediated CNS diseases. 

課程目標
 The course will first explain the basics of CNS immunology in the context of cellular functions and histological structures. Concepts including endogenous and exogenous immune resources of CNS, the function of meningeal lymphatics, and the origin of specific CNS immune cells will be introduced. This will be followed by a detailed study of the CNS and peripheral immune system interactions in the diseased brain. Acute brain injury (e.g. stroke or traumatic brain injury) and chronic autoimmune disease (e.g. multiple sclerosis) will be used as representative examples to explain how immune cells contribute to the pathology in the CNS. Group discussion of current research articles in neuroimmunology will be conducted in this course. Additional learning opportunities will be provided to the students by invited lectures from experts in the field. 
課程要求
 At the end of the course, students will be asked to complete a short in-depth essay which aims to ensure a comprehensive understanding of the current knowledge in the field. Students will be graded based on attendance, participation, and the essay. 
預期每週課後學習時數
  
Office Hours
 備註： TBA 
指定閱讀
 N/A 
參考書目
 Most recent 5-year research and review articles in the neuroimmunology field 
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 attendance 
20% 
 Although it is not required, send me a brief e-mail to explain absence in advance. Students who repeatedly absence or arrive late to the lecture will have their class attendance grade lowered. 
2. 
 participation/ discussion 
40% 
 Class participation is a very important part of the learning process in this course. You will be evaluated on the quality of your contributions and insights. Quality comments possess one or more of the following properties: *Offers different and unique, but relevant, perspective *Contributes to moving the discussion forward *Builds on other comments  
3. 
 essay 
40% 
 You will be rewarded with a perfect score as long as you actively consider the rationale of your essay and provide unique perspective in your essay. 
 
課程進度
週次
日期
單元主題
第1週
   Introduction to Neuroimmunology 
第2週
   Concept of CNS Immune Privilege 
第3週
   Glymphatic System 
第4週
   Meningeal Lymphatic System 
第5週
   CNS Tissue-Resident Macrophages- Microglia 
第6週
   Microglia & CNS Development 
第7週
   Microglia & Neonatal Brain Injury 
第8週
   Microglia & Acute Brain Injury 
第9週
   Microglia & Cerebrovascular Diseases 
第10週
   CNS Tissue-Resident Macrophages- Perivascular Macrophages 
第11週
   Perivascular macrophages & Cerebrovascular Diseases 
第12週
   Mononuclear Phagocytic System (MPS) 
第13週
   MPS - Blood-Derived Macrophages & CNS Diseases (I) 
第14週
   MPS - Blood-Derived Macrophages & CNS Diseases (II) 
第15週
   T cell & CNS Diseases 
第16週
   B cell & CNS Diseases 
第17週
   Innate Lymphoid Cells & CNS Diseases 
第18週
   Trained Innate Immunity & CNS Diseases