課程名稱 |
神經迴路與行為-進階篇 Neural Circuits and Behaviors: The Advances |
開課學期 |
109-2 |
授課對象 |
醫學院 腦與心智科學研究所 |
授課教師 |
姚皓傑 |
課號 |
GIBMS7017 |
課程識別碼 |
454 M0420 |
班次 |
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學分 |
2.0 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期一6,7(13:20~15:10) |
上課地點 |
基1203 |
備註 |
與王培育、吳恩賜、黃憲松、曾明宗合授 總人數上限:30人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1092GIBMS7017_ |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
Optogenetics, chosen as the "Method of the Year" in 2010 by Nature Methods and highlighted in the article on “Breakthroughs of the Decade” in Science, has revolutionized the way neuroscientists study the function of neural circuits underlying behaviors. Optogenetic approach is a powerful research approach to map neural circuits and study their functional roles. It is the combination of genetic and optical methods to allow reversibly control neuronal activity in targeted cells or circuits of living brain in the millisecond timescale. The field of optogenetics has made remarkable progress in mapping functional neural circuits and shown tremendous impact on behavioral neuroscience research. The course aims to enable students to understand the concepts of research questions, methodology and experimental designs through reading important optogenetic research literature focusing on the neurophysiology as well as behavioral functions of neural circuits. |
課程目標 |
The primary goal of the course is to provide students with a broad understanding of how to employ optogenetics in mouse model system to investigate neural circuits function, and help students develop an appreciation of the neural basis of complex behaviors. |
課程要求 |
Preparation and participation: students taking this course will be required to do a considerable amount of literature readings each week and take an active part in classroom discussions. |
預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
待補 |
參考書目 |
待補 |
評量方式 (僅供參考) |
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週次 |
日期 |
單元主題 |
第1週 |
2/22 |
Introduction |
第3週 |
3/08 |
Antidepressant actions of the Ketamine |
第5週 |
3/22 |
Ketamine antidepressant action and mPFC |
第6週 |
3/29 |
Defense behavior |
第9週 |
4/19 |
VTA and defensive behaviors |
第10週 |
4/26 |
Addiction |
第11週 |
5/03 |
Regulation of motivational behaviors |
第12週 |
5/10 |
The role of ZI in defensive behaviors |
第13週 |
5/17 |
Motor cortex reorganization |
第14週 |
5/24 |
Foraging behaviors |
第15週 |
5/31 |
VTA glutamatergic neurons and reinforcement |
第16週 |
6/07 |
Goal-directed social behaviors |
第17週 |
6/14 |
aggression modulation |