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課程名稱 |
細胞微機電及微流體導論
Introduction to Cellular BioMEMS and Biomicrofluidics |
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開課學期 |
108-2 |
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授課對象 |
工學院 應用力學研究所 |
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授課教師 |
許聿翔 |
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課號 |
AM7166 |
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課程識別碼 |
543EM5310 |
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班次 |
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學分 |
3.0 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期二7,8,9(14:20~17:20) |
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上課地點 |
應109 |
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備註 |
本課程以英語授課。
總人數上限：30人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1082AM7166_ |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
課程名稱: 細胞微機電及微流體導論
(Introduction to Cellular BioMEMS and Biomicrofluidics)
1.Cellular biomechanics: anatomy and physiology of cells, mechanics of cytoskeleton, cell-matrix interaction, focal adhesions, mechanical model, mechanoreceptors, mechanical behavior of cells: mitosis, migration, and introduction to infection induced cell abnormality.
2.Tissue Engineering: microcirculation, capillary anatomy, diffusion and convection, Starling law, osmotic pressure, interstitial flow, basics of angiogenesis and vasculogenesis.
3.BioMEMS: Photolithography, bulk micromachining, surface micromachining, micro-molding, plastic manufacturing.
4.Microfluidics: scaling laws, surface to volume ratio, hydraulic resistance, wall shear stress, diffusion, capillary flow, hydrodynamics in porous media.
5.Special topic: Cell-based chip for biotechnology - bioreactors, studies of mechanics of abnormal cells, cell sorting, cell trapping.
6.Special topic: BioMEMS for cell biology - substrate dependency of cells, cell-cell contact, cell migration.
7.Special topic: Tissue microengineering - 3D culture, angiogenesis, vasculogenesis, organ on a chip. |
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課程目標 |
(1) Introduce how to use basic mechanics to explain cell and tissue mechanics.
(2) Explain how to apply cell mechanics to the design of BioMEMS and Biomicrofluidic devices
(3) Understand the applications of BioMEMS and Biomicrofluidics in medical applications |
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課程要求 |
待補 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
Lecture notes |
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參考書目 |
Major Reference textbook: Introduction to BioMEMS, Albert Folch, CRC Press; 1st ed. (August 21, 2012)
Ch1 How do we make small things?
Ch2 Micropatterning of substrates and cells
Ch3 Microfluidics
Ch5 Cell-based chips for biotechnology
Ch6 BioMEMS for cell biology
Ch7 Tissue microengineering
Other Reference book：Essential Cell Biology, Bruce Albert, et al. Garland Science, 2nd ed. (September 25, 2003)
Ch17 Cytoskeleton
Ch19 Cell division
Introductory Biomechanics - From Cells to Organisms,
C. Ross Ethier and Craig A. Simmons, Cambridge University Press (April 9, 2007)
Ch2 Cellular biomechanics
Ch3 Hemodynamics
Ch4 The circulatory system
Ch5 Interstitial fluid flow
Fundamental of Microfabrication, Marc Madou, CRC Press
Ch1 Lithography
Ch2 Pattern transfer with dry etching technologies
Ch4 Wet bulk micromachining
Ch5 Surface micromachining.
Theoretical Microfluidics, HenrikBruus, Oxford University Press, (Nov 17, 2007)
Ch2 Governing equations
Ch3 Basic flow solutions
Ch4 Hydraulic resistance and compliance
Ch5 Diffusion |
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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第1週 |
3/03 |
Introduction to Lab-on-a-Chip systems (Micro Total Analysis Systems) + Photolithography |
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第2週 |
3/10 |
Photolithography |
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第3週 |
3/17 |
SU-8 Negative Photoresist |
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第4週 |
3/24 |
SU-8 Negative Photoresist & Soft-Lithography |
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第5週 |
3/31 |
Soft-Lithography |
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第6週 |
4/7 |
Cell Mechanics |
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第7週 |
4/14 |
Substrate dependency |
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第8週 |
4/21 |
Substrate dependency |
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第9週 |
4/28 |
Cell model |
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第10週 |
5/05 |
Bioreactor & review |
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第11週 |
5/12 |
Midterm |
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第12週 |
5/19 |
Endothelial cells, vasculogenesis, angiogenesis |
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第13週 |
5/26 |
Myocytes, Skeletal muscle, Cardiac myocyte, Neurons |
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第14週 |
6/02 |
Neuron Chip + Cancer research |
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第15週 |
6/09 |
Cancer research + Organ on a chip (實體課程)
進行課程問卷調查 |
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第16週 |
6/16 |
Student presentation (實體課程) |
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第17週 |
6/23 |
Student Project report due (by email) |
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