課程資訊
課程名稱
專題研究
Seminar 
開課學期
99-2 
授課對象
醫學工程學研究所  
授課教師
謝銘鈞 
課號
Biomed7002 
課程識別碼
548 M0040 
班次
10 
學分
全/半年
半年 
必/選修
選修 
上課時間
 
上課地點
 
備註
本課程中文授課,使用英文教科書。
總人數上限:20人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/992548M004010 
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課程概述

專題研究 

課程目標
無 
課程要求
1.每星期挑選一主題報告與同學進行討論。
2.同學分享每星期實驗進度,並由老師給予改善建議。 
預期每週課後學習時數
 
Office Hours
每週二 17:30~19:30 
指定閱讀
無 
參考書目
無 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
出席 
30% 
 
2. 
實驗紀錄 
30% 
 
3. 
口頭報告 
40% 
 
 
課程進度
週次
日期
單元主題
第1週
02/22  1. An aptamer siRNA chimera 2.L1-Mediated Colon Cancer Cell Metastasis Does Not Require Changes in EMT and Cancer Stem Cell Markers 
第2週
03/01  1. Why is Chitosan Mucoadhesive? 2. Covalently Combining Carbon Nanotubes 
第3週
03/08  老師出國暫停一次 
第4週
03/15  1. Simultaneous Delivery of siRNA and paclitaxel 2.Chondrogenesis of human mesenchymal stem cells mediated by the combination of SOX trio SOX5, 6, and 9 genes complexed with PEI-modified PLGA nanoparticles 
第5週
03/22  1. CD44 and EpCAM Cancer-Initiating Cell Markers 2. A route to brightly fluorescent carbon nanotubes 
第6週
03/29  1. The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo 
第7週
04/01  1.Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues 2. Multifunctional Nanoparticles Delivering Small Interfering RNA and Doxorubicin Overcome Drug Resistance in Cancer 3.CD133+ single cell-derived progenies of colorectal cancer cell line SW480 with different invasive and metastatic potential (因4/5清明節,故提早至04/01) 
第8週
04/12  期中考週 
第9週
04/19  1. Magnetic micro-manipulations to probe the local physical properties of porous scaffolds and to confine stem cells 2.Amphiphilic Methoxy Poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(2-dimethylaminoethyl methacrylate) Cationic Copolymer Nanoparticles as a Vector for Gene and Drug Delivery
 
第10週
04/26  98學年度碩二學生proposal 1. Utilizing In vitro and In vivo System (Model) to Assess the Roles of Cancer Stem Cells in Human Colorectal Cancer Metastasis. 2.Reversal of Multidrug Resistance Induced by Aptamer-Mediated siRNA and Drug Delivery System . 
第11週
05/03  1.SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma 
第12週
05/10  1.Nanoengineered Surfaces Enhance Drug Loading and Adhesion 2.Drug Delivery with Carbon Nanotubes for In vivo Cancer Treatment 
第13週
05/17  1.NF-kappaB inhibition improves the sensitivity of human glioblastoma cells 
第14週
05/24  1.Orally delivered thioketal nanoparticles loaded with TNF- –siRNA target inflammation and inhibit gene expression in the intestines 2.The promotion of siRNA delivery to breast cancer overexpressing epidermal growth factor receptor through anti-EGFR antibody conjugation by immunoliposomes 
第15週
05/31  1.Mining multi-item drug adverse effect associations in spontaneous reporting systems 2.Significance of site-specific prognosis of cancer stem cell marker CD44 in head and neck squamous-cell carcinoma 
第16週
06/07  1.Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imamging, and siRNA delivery 2.Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window 3.Orally delivered thioketal nanoparticles loaded with TNF- –siRNA target inflammation and inhibit gene expression in the intestines(佩芝原6/14,提前至6/7) 
第17週
06/14  1.A new family of folate-decorated and carbon nanotube-mediated drug delivery