課程資訊
課程名稱
分解性生醫材料
DEGRADABLE BIOMATERIALS 
開課學期
98-2 
授課對象
工學院  醫學工程學研究所  
授課教師
黃義侑 
課號
Biomed7015 
課程識別碼
548 M0310 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期四2,3,4(9:10~12:10) 
上課地點
 
備註
本課程中文授課,使用英文教科書。教室:基醫403。
總人數上限:50人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/982M0310 
課程簡介影片
 
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課程概述

一、課程簡介: 學分數:3 學分
Biodegradable (and/or bioabsorbable) biomaterials are widely used in sutures, bone plates, guiding of growth of tissues, drug delivery systems and other types of prostheses. In drug delivery systems, such polymers offer the great advantage of enabling site-specific or systemic administration of pharmaceutical agents without the need for subsequent retrieval of the delivery system. This course will provide a board spectrum of biodegradable polymers, ranging from synthesis, characterization, manufacturing… to medical applications. It will be useful to students who are new to the field and would like to understand more about the various properties and medical applications of biodegradable polymers.

課程內容:包括
 1. Introduction: Classification and mechanisms of biodegradation.
 2. Biodegradable polyesters: Lactide/glycolide polymers
 3. Biodegradable polyesters and tissue engineering
 4. Polyanhydrides
 5. Poly--Caprolactone and its copolymers
 6. Poly(ortho esters)
 7. Polyphosphazenes as new biomedical and bioactive materials
 8. Pseudopoly(amino acids)
 9. Natural biodegradable polymers: Albumin, collagen, and chitin/chitosan
10. Collagen and artificial skin
11. Liposome: Preparation and characterization
 12. Medical applications of liposomes: Drug delivery and gene therapy

二、先修課程:無

三、參考書目:
1. Chasin M and Langer R: Biodegradable Polymers as Drug Delivery Systems. Marcel Dekker, 1990, New York.
2. Hollinger JO: Biomedical Applications of Synthetic Biodegradable Polymers. CRC Press, 1995, Boca Raton
3. Lanza RP, Langer R and Vacanti J: Principles of Tissue Engineering. Academic Press, 2000, San Diego.
 

課程目標
This course will emphasize on the green plastcs, biodegradable macromolecules and polymers. That will be useful to students who are new to the field and would like to understand more about the various properties and medical applications of biodegradable polymers. 
課程要求
無 
預期每週課後學習時數
 
Office Hours
 
參考書目
1. Chasin M and Langer R: Biodegradable Polymers as Drug Delivery Systems.
Marcel Dekker, 1990, New York.
2. Hollinger JO: Biomedical Applications of Synthetic Biodegradable Polymers.
CRC Press, 1995, Boca Raton
3. Lanza RP, Langer R and Vacanti J: Principles of Tissue Engineering.
Academic Press, 2000, San Diego.
 
指定閱讀
於上課時指定參考資料閱讀 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
平時考 
70% 
 
2. 
oral presentation + ppt 
20% 
 
3. 
Term paper 
10% 
 
 
課程進度
週次
日期
單元主題
第1週
2/25  Introduction(舊1,2,3,4,5/新1,2,3,4,7) 
第2週
3/04  Biomedical-0 outline(舊1,2,3,4,5/新1,2,3,4,6,7) 
第3週
3/11  Biomedical-0 outline-2(舊1,2,3,4,5/新1,2,3,4,6,7) 
第4週
3/18  PLA, PLGA, PGA(舊1,2,3,4,5/新1,2,3,4,7) 
第5週
3/25  medical product(舊1,2,3,4,5/新1,2,3,4,7) 
第6週
4/01  polymer scaffold processing(舊2,3,4,5,6/新1,2,3,4,5,7) 
第7週
4/08  biodegradable ECM(舊1,2,3,4,5/新1,2,3,4,7) 
第8週
4/15  scaffold(舊1,2,3,4,5/新1,2,3,4,7) 
第9週
4/22  Mid-term exam 
第10週
4/29  PCL-PEG, POE(舊1,2,3,4,5/新1,2,3,4,7) 
第11週
5/06  Poly(ortho esters)
(舊1,2,3,4,5/新1,2,3,4,7) 
第12週
5/13  collagens as biomaterial(舊1,2,3,4,5/新1,2,3,4,7) 
第13週
5/20  Collagen_Tissue_Engineering(舊1,2,3,4,5/新1,2,3,4,7) 
第14週
5/27  Hyaluronan-based Biomaterials in Tissue Engineering(舊1,2,3,4,5/新1,2,3,4,7) 
第17週
6/17  Final exam(含問卷)