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課程名稱 |
生醫奈米
Nanobioscience |
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開課學期 |
102-1 |
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授課對象 |
學程 奈米科技學程 |
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授課教師 |
謝銘鈞 |
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課號 |
Biomed7044 |
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課程識別碼 |
548 M0740 |
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班次 |
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學分 |
3 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期四2,3,4(9:10~12:10) |
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上課地點 |
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備註 |
本課程中文授課,使用英文教科書。
總人數上限：20人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1021Biomed7044 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
1. Structure, Properties, and Characterization of nano-materials
2. Drug delivery system (Dendrimer, nanoparticle, micelle)
3. Drug delivery system (Liposome, chitosan)
4. Non-viral vector for gene transfection
5. Seminar (I) (design and paper review)
6. Targeting contrast agent (microbubbles, SPIO, etc)
7. Bionanotechnology-lab tour
8. MID-TERM Exam
9. Nanotechnology in caner treatment
10. PDT & PDD for nano-medicine
11. Trigger release of nano-medicine (Ultrasound, laser, magnetic, RF )
12. Hyperthermia for magnetic nanoparticles
13. Seminar (II) (design and paper review)
14. Animal model in nano-medicine
15. Industrial survey (visit research institute and pharmaceuticals)
16. FINAL Exam
對象：臨床工程組、材料組
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課程目標 |
培養學生結合化學材料與奈米科技應用於生物醫療上的能力，並且廣泛的介紹各類顯影技術於研究以及醫療上的應用，開拓學生於生物醫療上的視野，藉此啟發學生對於藥物設計的靈感與興趣。 |
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課程要求 |
無 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
無 |
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參考書目 |
教科書：
2004 Biomaterials for delivery and targeting of proteins and nucleic acids
2006 Nanotechnology for Cancer Therapy
2006 Pharmaceutical biotechnology
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
Mid-term Exam |
20% |
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2. |
Final Exam |
20% |
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3. |
Presentation |
30% |
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4. |
Report |
30% |
The content requires at least two pages of A4 with font 14 typing in double space, and schema is encourage
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週次 |
日期 |
單元主題 |
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第1週 |
9/12 |
Introduction and Characterization of Nano-materials 謝銘鈞 |
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第2週 |
9/19 |
中秋節放假 |
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第3週 |
9/26 |
MRI contrast agent (SPIO, etc) 蕭仲凱 |
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第4週 |
10/03 |
Drug delivery system (Dendrimer, micelle & aptamer) 謝銘鈞
Ref.: 1. Doxorubicin delivery by polyamidoamine dendrimer conjugation and photochemical internalization for cancer therapy, Journal of Controlled Release, 122 (2007) 39-46. 2. Characterization of the Uptake and Intracellular Trafficking of G4 Polyamidoamine Dendrimers. Australian Journal of Chemistry (2011) 64 (3) 302-308. |
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第5週 |
10/10 |
國慶日放假 |
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第6週 |
10/17 |
Seminar (I) (design and journal watch) 謝銘鈞 |
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第7週 |
10/24 |
Nanotechnology in cancer management 謝銘鈞
Ref.: 1. Reversal of doxorubicin-resistance by multifunctional nanoparticles in MCF-7/ADR cells. Journal of controlled release, Available online 22 March 2011. 2. Self-assembled star-shapedchlorin-corepoly(ε-caprolactone)- poly(ethylene-glycol) diblock copolymer micelles for dual chemo-photodynamic therapies, Biomaterials, 29 (2008) 3599-3608. 3. Dual chemotherapy and photodynamic therapy in a HT-29 human colon cancer xenograft model using SN-38-loaded chlorin-core star block copolymer micelles, Biomaterials, 30 (2009) 3614-3625.
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第8週 |
10/31 |
Non-viral vector for gene transfection 謝銘鈞
Ref.: 1. Non-toxic photo-triggered gene transfection by PAMAM-porphyrin conjugates, Journal of Controlled Release, 129 (2008) 200-206. 2. Effect of chitosan-alginate nanoparticles and ultrasound on the efficiency of gene transfection of human cancer cells, Journal of Gene Medicine, 11 (2009). 3. The use of PEI–DNA to topically deliver hTERT to promotehair growth. Gene therapy, May 19, 2011, online
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第9週 |
11/07 |
期中考 |
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第10週 |
11/14 |
pH-sensitive, thermosensitive nano-materials 彭正良/謝銘鈞
Ref.: 1. Development of pH sensitive 2-(diisopropylamino)ethyl methacrylate based nanoparticles for photodynamic therapy. Nanotechnology ( 2010); 21(15):155103. 2. Development of thermosensitive poly(n-isopropylacrylamide-co-((2-dimethylamino) ethylmethacrylate))-based nanoparticles forcontrolled drug release. Nanotechnology ( 2011) 3. Multimodal Image-Guided Photothermal Therapy Mediated by 188Re-Labele Micelles Containing a Cyanine-Type Photosensitizer. ACS Nano, June 14, 2011 online
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第11週 |
11/21 |
Seminar (II) (design and journal watch) 謝銘鈞 |
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第12週 |
11/28 |
Therapeutic Ultrasound in Biomedicine 林文澧 |
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第13週 |
12/05 |
Cell image 林峰輝 |
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第14週 |
12/12 |
Nano-medicine for PDT, PCI & PDD 謝銘鈞 |
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第15週 |
12/19 |
Drug delivery system (Liposome, chitosan) (12/19) 黃義侑 |
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第16週 |
12/26 |
Seminar (III) (design and journal watch) 謝銘鈞 |
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第17週 |
1/02 |
Industrial survey for nanomedicine (pharmaceuticals) (1/2) 許源宏 |
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第18週 |
2014/01/09 |
期末考 (1/9) (20%) 謝銘鈞 |
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