|
課程名稱 |
細胞技術的產學與臨床應用
Cell Technology: From Basic Research to Clinical/ Industrial Application |
|
開課學期 |
113-2 |
|
授課對象 |
生物資源暨農學院 生物科技研究所 |
|
授課教師 |
林劭品 |
|
課號 |
BFN5006 |
|
課程識別碼 |
615EU0040 |
|
班次 |
|
|
學分 |
3.0 |
|
全/半年 |
半年 |
|
必/選修 |
選修 |
|
上課時間 |
星期五6,7,8(13:20~16:20) |
|
上課地點 |
食研222 |
|
備註 |
本課程以英語授課。
總人數上限：25人 |
|
|
|
|
課程簡介影片 |
|
|
核心能力關聯 |
核心能力與課程規劃關聯圖 |
|
課程大綱
|
|
為確保您我的權利,請尊重智慧財產權及不得非法影印
|
|
課程概述 |
The interdisciplinary field of (stem) cell technology encompasses a wide array of topics, including stem cell biology, organoid development, biomaterials in stem cell research, and the implementation of innovative techniques such as microChips or organ-on-chips. Understanding the regulation of stem cell therapies is crucial for navigating the ethical and legal landscape surrounding their use in research and clinical settings. Moreover, a comprehensive study also involves exploring the social implications of stem cell research and assisted reproductive technology, addressing ethical concerns and public perceptions. In addition to advancing scientific knowledge, there is a growing emphasis on translating research findings into practical applications, with a focus on industrial applications and the establishment of business plans or branding strategies to facilitate the commercialization of stem cell-based products and therapies. |
|
課程目標 |
Gain the knowledge of certain perspectives of cell technologies and their application in medical, animal, agriculture and environmental solutions
Acquire fundamental knowledge in stem cell biology
Understand the power and basic mechanism of cellular reprogramming to de-differentiation
Be able to describe the differences and potential/application of 2D and 3D cell models and organoids
Understand the common molecular mechanisms across “Stem Cell Differentiation”, “Sex-Chromosome Dosage Compensation”, ”Parental-Origin Specific Genomic Imprinting”, “Somatic Cell Nuclear Transfer (Dolly the sheep)”, ”Induced Pluripotent Stem Cell Reprogramming”
Explain the concepts of Epigenomics in lay language and scientific terms
Significance of Cell Technology in Regenerative Medicine, Pharmaceutical Industry, Toxicology Testing, Cancer Therapy, Species Preservation, ..
If possible, design experiments to tackle Cell Biology levels of hypothesis or Develop Business model
|
|
課程要求 |
Minimum requirement: High School Biology, Molecular and Cell Biology Background
Preferably have taken one of the following courses: Biology, Cell Biology, Genetics, Molecular Biology, |
|
預期每週課後學習時數 |
Expected study hours 1-4 hours /week depending on different phases of the course progress |
|
Office Hours |
另約時間 備註： Please make appointment by Email (shaupinglin@ntu.edu.tw) or LINE |
|
指定閱讀 |
Stem Cells: Biology and application/Mary L. Clarke, Jonathan Frampton. 2020
Germ cell development: methods and protocols/edited by Macro Barchi, Massimo De Felici. 2024
Germline stem cells: methods and protocols/edited by Michael Buszczak. 2023
|
|
參考書目 |
Chia-Ling Wu, 2023.
Making Multiple Babies: Anticipatory Regimes of Assisted Reproduction |
|
評量方式
(僅供參考) |
|
|
針對學生困難提供學生調整方式 |
|
上課形式 |
以錄音輔助, 以錄影輔助 |
|
作業繳交方式 |
書面報告取代口頭報告, 口頭報告取代書面報告, 團體報告取代個人報告, 學生與授課老師協議改以其他形式呈現 |
|
考試形式 |
延後期末考試日期(時間), 書面(口頭)報告取代考試, 考試取代書面(口頭)報告 |
|
其他 |
由師生雙方議定 |
|
|
週次 |
日期 |
單元主題 |
|
Week 0 |
06/06/2025 |
Written Assignment Due:
(1) Review; (2) Public Science Article; (3) Scientific Proposal; (4) Business Proposal |
|
Week 1 |
2025/2/21 |
Introduction and discussion of cell technology and ways to application
Foundations of Cell and Molecular Biology: Highlighting Stem Cell Biology and Assisted Reproductive Biology
Prof. Shau-Ping Lin |
|
Week 2 |
2025/2/28 |
Bank Holiday
Group Assignment: "Joy" The movie behind the journey towards the 1st human IVF baby.
1. What's the significance (both for the social perspectives and biological/scientific perspectives) of assisted reproductive technology (which could help subfertility/infertility couple, animals...)?
2. During the trouble shooting of the in vitro fertilization (IVF) condition, what's the key reagent causing toxicity?
3. If you have time, please try to search for the various assisted reproductive techniques, including but not limited to: (in abbreviation) IVF, IUI, PGS, PGD,...and their potential as well as risks/social impacts. |
|
Week 3 |
2025/3/7 |
Stem Cell Biology and Organoid
Prof. Shau-Ping Lin
1st trial: Short Presentation/Show and Tell from Students
|
|
Week 4 |
2025/3/14 |
Assisted Reproductive Biology: From Basic Research, Animal Science and Technology, to Clinical Practice and Business
Prof. Shau-Ping Lin |
|
Week 5 |
2025/03/21 |
"The Boundary of Regenerative Medicine" (Bridging into Stem Cell Industry)
Invited Speaker: Shih-Yang Wu
|
|
Week 6 |
2025/03/28 |
“Genomics Applications in Prenatal Screening”
Prof. Ching from Tzu-Chi University has been collaborating with obstetrician-gynecologists (OB-GYNs) to interpret genetic testing results, with a focus on clinical applications. She also made an amazing documentary on human genetics and stories of the patients. |
|
Week 7 |
04/04/2025 |
Bank Holiday: Students' Assignment |
|
Week 8 |
04/11/2025 |
Social Science Prospectives of Assisted Reproductive Biology
Prof./Director Chia-Ling Wu (Social Science Department) |
|
Week 9 |
04/18/2025 |
Putting a Price to the Biotechnological Product/Business
Prof. Julie Sun |
|
Week 10 |
04/25/2025 |
Regulatory Science
Prof. Kanda (National Institute of Health Science, Japan) |
|
Week 11 |
05/02/2025 |
Germinal Stem Cell Biology Conference Highlights
BioHacker Documentary
Students Assignment |
|
Week 12 |
05/09/2025 |
NeuroDegenerative Diseases
Multiple System Atrophy Conference Highlights
BioHacker Documentary
Students Assignment |
|
Week 13 |
05/16/2025 |
Graphin
AI assisted Drug Design
Students' Show Case |
|
Week 14 |
05/23/2025 |
Branding in Biotechnology
Prof. Shih-Chia Wu (CHK University, Hong Kong) |
|
Week 15 |
05/30/2025 |
Bank Holiday: Preparation for the submission of End of Term Report
|
|