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課程名稱 |
細菌蛋白質分泌系統
Bacterial Protein Secretion Systems |
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開課學期 |
108-1 |
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授課對象 |
生物資源暨農學院 植物病理與微生物學系 |
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授課教師 |
賴爾 |
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課號 |
PPM5066 |
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課程識別碼 |
633 U1360 |
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班次 |
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學分 |
2.0 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期二3,4(10:20~12:10) |
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上課地點 |
博雅306 |
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備註 |
總人數上限：10人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1081PPM5066_ |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
Protein secretion systems play central roles in the export or import of macromolecules in both prokaryotic and eukaryotic cells. This course will introduce how proteins are translocated across membranes and secreted outside of bacterial cells or even transported into the hose cells. The biological functions of secretion systems will be also discussed with focus on pathogenic bacteria. The course will cover 1) lectures and 2) paper discussion. |
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課程目標 |
1) obtain the basic knowledge in the mechanisms and biological functions of bacterial
protein secretion systems
2) train the students to critically read and evaluate the experimental data.
3) cultivate the students for the ability to identify important questions and design the
adequate experiments to address the questions. |
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課程要求 |
Classroom: A236, 2F, Agricultural Technology Building, Academia Sinica
Time: 10am-12pm, Every Tuesday |
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預期每週課後學習時數 |
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Office Hours |
另約時間 |
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指定閱讀 |
待補 |
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參考書目 |
待補 |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
Midterm exam |
20% |
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2. |
Final exam |
30% |
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3. |
Paper presentation |
30% |
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4. |
Class attendance and participation |
20% |
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週次 |
日期 |
單元主題 |
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第1週 |
9/10 |
General introduction in protein translocation in bacteria |
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第2週 |
9/17 |
Type I secretion system (T1SS) |
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第3週 |
09/24 |
Paper discussion (General secretion) |
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第4週 |
10/01 |
Type II secretion system (T2SS) |
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第5週 |
10/08 |
Paper discussion (T1SS) |
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第6週 |
10/15 |
Type IV secretion system (T4SS) |
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第7週 |
10/22 |
Paper discussion (T2SS) |
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第8週 |
10/29 |
Type III secretion system (T3SS) |
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第9週 |
11/05 |
Paper discussion (T4SS) |
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第10週 |
11/12 |
Type V secretion system (T5SS) |
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第11週 |
11/19 |
Paper discussion (T3SS) |
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第12週 |
11/26 |
Type VI secretion system (T6SS)
Due for mid-term take-home exam of General Secretion, T1SS, T2SS, and T4SS
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第13週 |
12/03 |
Paper discussion (T5SS) |
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第14週 |
12/10 |
T9SS and T7SS |
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第15週 |
12/17 |
Paper discussion (T6SS) |
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第16週 |
12/24 |
Extracellular vesicles in host-microbe interactions |
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第17週 |
12/31 |
Paper discussion (T9SS) |
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第18週 |
01/07 |
Due for final take-home exam of T3SS, T5SS, T6SS, and other secretion systems |
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