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課程名稱 |
後生遺傳學
Epigenetics |
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開課學期 |
110-1 |
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授課對象 |
生物資源暨農學院 生物科技研究所 |
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授課教師 |
林劭品 |
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課號 |
Biot8001 |
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課程識別碼 |
642ED0020 |
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班次 |
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學分 |
3.0 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期一2,3,4(9:10~12:10) |
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上課地點 |
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備註 |
本課程以英語授課。曾修過[分子生物學]，上課地點：生技所R415與林詩舜合授
總人數上限：30人
外系人數限制：20人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1101Biot8001_ |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
Introduction—Epigenetic Overview
DNA methylation and genome defense
RNAi and heterochromatin
Evolution of mammalian epigenetic control systems
Epigenetics and development
Epigentics and human disease
X-inactivation
Genomic imprinting in mammals
Genomic imprinting in plants
Epignetics and reprogramming
Epigenetics in assisted reproductive techniques
Applied epigenetics: flowering plants and tissue engineering |
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課程目標 |
Course description: This graduate course aims to introduce basic epigenetic concepts and research techniques available to address epigenetic questions in mammals as well as other organisms. Students are expected to develop the ability to critically evaluating and interpreting published research articles. They will also learn to extract information from international conferences by listening to experts of each field introducing their research (as in the CD-ROM). |
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課程要求 |
Having either Molecular Biology or Genetics background. We expect the students to be familiar with basic knowledge of transcription (from DNA to RNA), translation (from mRNA to protein), post-transcriptional regulation (RNA stability control, availability of the mRNAs to be translational control), as well as the cis-acting (specific DNA sequences like promoters, enhancers,...) and trans-acting factors (usually proteins, including transcription factors, activators, etc). |
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預期每週課後學習時數 |
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Office Hours |
另約時間 備註： with prior appointments please |
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指定閱讀 |
Assigned review papers. |
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參考書目 |
待補 |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
Discussion over the class/ Homework |
20% |
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2. |
Open Book/Internet Mid term Exam |
25% |
Students are encouraged to discuss before the exam, group notes are also allowed |
3. |
Group oral presentation and author/reviewer role playing |
30% |
Group mark will be given |
4. |
Final Written Report |
25% |
Student can choose from "Reviewers' comments", "News and Views", "Proposal", "mini-review" formats |
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週次 |
日期 |
單元主題 |
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第1週 |
9/20 Mid-Autumn Festival |
~~~No Class~~~ |
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第2週 |
9/27 |
Epigenetics Introduction + microRNAs in plants (SS Lin)
Recording: https://youtu.be/1_jUVG0TlLg |
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第4週 |
10/04 |
siRNA and miRNA (SS Lin)
Recording: https://youtu.be/uaZKWLs0L18 |
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第5週 |
10/11 National Day |
~~~No Class~~~ |
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第6週 |
10/18 |
Epigenetic regulatory mechanisms and phenomenons (SS Lin) |
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第7週 |
10/25 |
Homework explanation (SS Lin) |
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第8週 |
11/01 |
Experimental epigenetic reprogramming (SP Lin) |
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第9週 |
11/08 |
Physiological epigenetic reprogramming (SP Lin)
Summary for the pre-exam materials (SS Lin; SP Lin) |
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第10週 |
11/15 |
NTU Festival_No class |
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第11週 |
11/22 Midterm exam |
期中考試 Open book/internet exam |
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第12週 |
11/29 SP Lin |
Transposable Element Modulation/ 3D genomic structure |
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第13週 |
12/06 SP Lin |
Epigenetic modifiers as drug targets/ Epigenetic editing as a new frontier?/ Guided original paper discussion
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第14週 |
12/13 |
Students' Presentation Part I
Group4 |
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第15週 |
12/20 |
Students' presentation Part Ii
Group1 & Group2 |
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第16週 |
12/27 |
IOB Frontiers in Biotechnology Conference |
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第17週 |
01/03 |
Final Written Report Preparation
(News and Views, Mini-review, reviewers' comments, pre-proposal format) |
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第18週 |
01/10 |
Hard deadline for final written report submission 11:50 am on 2022/January/10th
Group3 |
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