課程資訊
課程名稱
 後生遺傳學
EPIGENETICS 
開課學期
 98-1 
授課對象
 生物資源暨農學院  生物科技研究所  
授課教師
 林劭品 
課號
 Biot8001 
課程識別碼
 642ED0020 
班次
  
學分
 3 
全/半年
 半年 
必/選修
 必修 
上課時間
 星期五2,3,4(9:10~12:10) 
上課地點
 生技所410 
備註
 本課程以英語授課。與林詩舜合開
限博士班
總人數上限：20人
外系人數限制：15人 
  
課程簡介影片
 
核心能力關聯
 核心能力與課程規劃關聯圖
課程大綱
為確保您我的權利,請尊重智慧財產權及不得非法影印
課程概述

This course aims to introduce the phenomenon as well as the mechanisms of Epigenetics in both mammal and plant system.

Introduction—Epigenetic Overview
DNA methylation and genome defense
RNAi and heterochromatin
Evolution of mammalian epigenetic control systems
Epigenetics and development
Epigentics and human disease
X-inactivation
Genomic imprinting in mammals
Genomic imprinting in plants
Epignetics and reprogramming
Epigenetics in assisted reproductive techniques
Applied epigenetics: flowering plants and tissue engineering
 

課程目標
 Course description: This graduate course aims to introduce basic epigenetic concepts and research techniques available to address epigenetic questions in mammals as well as other organisms. Students are expected to develop the ability to critically evaluating and interpreting published research articles. They will also learn to extract information from international conferences by listening to experts of each field introducing their research (as in the CD-ROM). 
課程要求
 Have basic knowledge on Molecular Biology and Biochemistry 
預期每週課後學習時數
  
Office Hours
 備註： 2pm-5pm on Thursday afternoons 
指定閱讀
  
參考書目
 Epigenetics, Edited by C. David Allis, Thomas Jenuwein, Danny Reinberg, Marie-Laure Caparros, Cold Spring Harbor Laboratory Press 
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 Mid-term exam 
30% 
 Open book style of exam 
2. 
 Oral presentation 
30% 
 Students will be divided into 3 groups for three selected topics. The presenting group need to summarize the selected original papers and present/defend in a journal club format. Students in the presenting group will share the same mark. The students from the 2 non-presenting groups are responsible for asking questions and be marked by the quality and quantity of the questions. 
3. 
 General participation during the class 
10% 
  
4. 
 End of the Term paper report 
30% 
 A "News and Views", "Mini-Review" or "Preview" style paper on any topics introduced in the class  
 
課程進度
週次
日期
單元主題
第1週
 9/18  Introduction to Epigenetics (SP) 
第2週
 9/25  Small TNA silencing in plants (I): microRNAs (SS) 
第3週
 10/02  Small TNA silencing in plants (II): tasiRNAs (SS) 
第4週
 10/09  Small RNA in mammals (SP) 
第5週
 10/16  International Invited Speakers 
第6週
 10/23  DNA methylation and genomic imprinting (SP) 
第7週
 10/30  DNA methylation in plants (SS) 
第8週
 11/06  Histone variants and modifications (SP + 鄭清文) 
第9週
 11/13  Open book Midterm exam + international invited speakers 
第10週
 11/20  The PolyComb Groups (SP) 
第11週
 11/27  The PolyComb Groups and Trithorax in plants (SS) 
第12週
 12/04  Genomic imprinting in plants (SS) 
第13週
 12/11  Epigenetics in Development and Disease (SP) 
第14週
 12/18  Epigenetics and Genome Defense (SS) 
第15週
 12/25  1st presentation from students 
第16週
 1/01  2nd presentation from students 
第17週
 1/08  3rd presentation from students 
第18週
 1/15  Final Paper submission