課程資訊
課程名稱
 後生遺傳學
Epigenetics 
開課學期
 106-1 
授課對象
 生命科學院  基因體與系統生物學學位學程  
授課教師
 林劭品 
課號
 Biot8001 
課程識別碼
 642ED0020 
班次
  
學分
 3.0 
全/半年
 半年 
必/選修
 選修 
上課時間
 星期一6,7,8(13:20~16:20) 
上課地點
 生技所415 
備註
 本課程以英語授課。與林詩舜合授
總人數上限：20人
外系人數限制：15人 
Ceiba 課程網頁
 http://ceiba.ntu.edu.tw/1061Biot8001_Epigene 
課程簡介影片
 
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課程概述

INTRODUCTION—EPIGENETIC OVERVIEW
DNA METHYLATION AND GENOME DEFENSE
RNAI AND HETEROCHROMATIN
EVOLUTION OF MAMMALIAN EPIGENETIC CONTROL SYSTEMS
EPIGENETICS AND DEVELOPMENT
EPIGENTICS AND HUMAN DISEASE
X-INACTIVATION
GENOMIC IMPRINTING IN MAMMALS
GENOMIC IMPRINTING IN PLANTS
EPIGNETICS AND REPROGRAMMING
EPIGENETICS IN ASSISTED REPRODUCTIVE TECHNIQUES
APPLIED EPIGENETICS: FLOWERING PLANTS AND TISSUE ENGINEERING
 

課程目標
 Course description: This graduate course aims to introduce basic epigenetic concepts and research techniques available to address epigenetic questions in mammals as well as other organisms. Students are expected to develop the ability to critically evaluating and interpreting published research articles. They will also learn to extract information from international conferences by listening to experts of each field introducing their research (as in the CD-ROM). 
課程要求
 Basic knowledge in Molecular Biology
 
預期每週課後學習時數
  
Office Hours
 另約時間 
指定閱讀
 待補 
參考書目
 待補 
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 In class discussion 
30% 
 Group Score 
2. 
 Open book midterm exam 
25% 
 Can submit revised answers for bonus within 2 weeks after the exam 
3. 
 Oral presentation/ Author-Reviewer Role Playing 
25% 
 Group Score 
4. 
 Written Report 
20% 
 "News and Views", "Mini-review" or "Reviewer's comments" format; Maximum 3 pages (excluding references and figures) 
 
課程進度
週次
日期
單元主題
第1週
 9/11  SP Lin: Introduction of Epigenetics 
第2週
 9/18  Introduction of functional small RNAs 
第3週
 9/25  SP Lin: Epigenetics in Development and Regenerative Medicine (ChIP and meDIP) 
第4週
 10/02  SP Lin: Epigenomics in senescence and aging 
第5週
 10/09  Off on Oct/09, group discussion on Sept 30th or any other agreed time within each group 
第6週
 10/16  SP Lin: Epigenomic modulators as drug targets 
第7週
 10/23  RNA-Directed DNA Methylation (RdDM) (1) 
第8週
 10/30  RNA-Directed DNA Methylation (RdDM) (2) 
第9週
 11/06  Open book midterm exam 
第10週
 11/13  SS Lin: RNA-Directed DNA Methylation (RdDM) (3) 
第11週
 11/20  SP Lin: Basic bioinformatic analysis for tackling epigenomic datasets (TA: Evan Tu) 
第12週
 11/27  Prof. Frederic Berger (Academia Sinica) 
第13週
 12/04  SP Lin: Genomic Imprinting and Sex chromosome dosage compensation 
第14週
 12/11  Dr. ROCIO ISABEL DIAZ DE LA GARZA 
第15週
 12/18  SP Lin: Students Showtime on Selected Topic(s)/ Author-Reviewer Role Playing 
第16週
 12/25  SS Lin: Students Showtime on Selected Topic(s) 
第17週
 1/01  Off to prepare for Written Report on "News and Views", "Mini-reviews" or "Reviewers' comments" format