課程資訊
課程名稱
 後生遺傳學
Epigenetics 
開課學期
 102-1 
授課對象
 生命科學院  基因體與系統生物學學位學程  
授課教師
 林劭品 
課號
 Biot8001 
課程識別碼
 642ED0020 
班次
  
學分
 3 
全/半年
 半年 
必/選修
 必修 
上課時間
 星期一5,6,7(12:20~15:10) 
上課地點
 生技所415 
備註
 本課程以英語授課。與林詩舜合開
限博士班
總人數上限：20人
外系人數限制：15人 
Ceiba 課程網頁
 http://ceiba.ntu.edu.tw/1021Epigenetics 
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課程概述

Introduction–Epigenetic Overview
DNA methylation and genome defense
RNAi and heterochromatin
Evolution of mammalian epigenetic control systems
Epigenetics and development
Epigentics and human disease
X-inactivation
Genomic imprinting in mammals
Genomic imprinting in plants
Epignetics and reprogramming
Epigenetics in assisted reproductive techniques
Applied epigenetics: flowering plants and tissue engineering
 

課程目標
 Course description: This graduate course aims to introduce basic epigenetic concepts and research techniques available to address epigenetic questions in mammals as well as other organisms. Students are expected to develop the ability to critically evaluating and interpreting published research articles. They will also learn to extract information from international conferences by listening to experts of each field introducing their research (as in the CD-ROM). 
課程要求
 Basic knowledge in Molecular Biology 
預期每週課後學習時數
  
Office Hours
  
指定閱讀
 Assigned original papers and reviews 
參考書目
  
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 Open book midterm exam 
30% 
  
2. 
 Participation in the discussion sessions 
20% 
  
3. 
 Students show time: Author/Reviewer role playing 
30% 
  
4. 
 End of term written report 
20% 
 In the format of "Minireview" or "News and Views" or "Preview" or "Primer" or "Reviewers' comments" 
 
課程進度
週次
日期
單元主題
第1週
 Sept/9  Introduction of Epigenetics (SP Lin) 
第2週
 Sept/16th  Epigenetic Phenomena and Mechanisms (SP Lin) 
第3週
 Sept/23rd  Small RNA word in plants (I) (SS Lin) 
第4週
 Sept/30th  Small RNA word in plant (II) (SS Lin)
 
第5週
 Oct/7th  Establishment, Erasure & Dynamics of Epigenetic States: Lessons from Stem cells and Germ cells (SP Lin) 
第6週
 Oct/14th  summary of pre-exam materials in Animal Epigenetics part and preparation of the 8th Asia Epigenomics conference (SP Lin) 
第7週
 Oct/21st  Dr. Bi-Tzen Juang (UCSF): siRNA induced histone modification on neural lineage 
第8週
 Oct/28th  Long non-coding RNA and RNA mediated DNA methylation (RdDM) (SS Lin) 
第9週
 Nov/4th  Open Book Midterm Exam 
第10週
 Nov/11th  Dr. Antonin Morillon (Institute Curie, France); Discussion of Midterm exam papers and the take home messages for the 8th Asia Epigenomics/2nd Taipei Epigenetics meeting (SP Lin) 
第11週
 Nov/18th  Gene silencing Vs. Autophagy ( SS Lin)
 
第12週
 Nov/25th  (SS Lin and SP Lin) Authors/Reviewers role playing part I (Plant?) 
第13週
 Dec/2nd  Dec 2nd (SP Lin) Authors/Reviewers role playing part II 
第14週
 Dec/9th  Introduction of Prof. Frederic Chedin’s work (SP Lin) 
第15週
 Dec/16th  Introduction of Prof. Marjori Matzke’s work (SS Lin)
（Dec 17th Prof. Marjori Matzke; Prof. Frederic Chedin; UC Davis) 
第16週
 Dec/23rd  (SS Lin and SP Lin) Authors/Reviewers role playing part III 
第17週
 Dec/30th  (SS Lin and SP Lin) Authors/Reviewers role playing part IV 
第18週
 2014/01/06  Final report due before 16:30 pm