課程資訊
課程名稱
動物基因轉殖與複製技術
TRANSGENIC AND CLONING TECHNOLOGY IN ANIMAL 
開課學期
96-2 
授課對象
生物資源暨農學院  生物科技研究所  
授課教師
宋麗英 
課號
Biot8005 
課程識別碼
642ED0060 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期一5,6,7(12:20~15:10) 
上課地點
生技所410 
備註
本課程以英語授課。本課程以英語授課。本課程以英語授課。本課程以英
限博士班
總人數上限:10人 
 
課程簡介影片
 
核心能力關聯
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課程大綱
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課程概述

Course outlines as following:
Part I : Transgenic animals
1.Introduction of transgenic animals
2.Generation of transgenic animals
3.Factors of affecting transgenic animal production
4.Transgenic animal model system
5.Applications of transgenic farm animals
Part II: Somatic cell nuclear transfer (SCNT) in animal
1.An overview of SCNT and nuclear reprogramming
2.Nuclear transfer technology
3.Somatic nuclear transfer in rodent species
4.Somatic nuclear transfer in domestic animal species
5.Nuclear remodeling by Xenopus egg extract
6.In vitro reprogramming of nuclei- induced pluripotent stem (iPS) cells
7.Mechanisms of epigenetic regulation in embryo development
8.Global patterns of methylation and histone modification
9.Genomic imprinting
10.Developmental capacity of ESCs from cloned embryos
11.Trophectoderm and placental defects in cloned embryos
12.From nuclear transfer to embryonic stem cells in mouse
13.Applications of cloning, reproductive vs. therapeutic cloning
14.Ethical concern of somatic nuclear transfer cloning 

課程目標
Animal transgenesis and nuclear transfer (NT) technology are powerful tools for understanding the cellular and molecular aspects of gene expression in embryo development. This course will provide students a state of the art of animal transgenesis and somatic cell nuclear cloning, as well as its applications. Students will be asked to present in particular topic they were assign after extensive review and discussion. Guest speakers will plan to invite for the lectures as necessary.  
課程要求
 
預期每週課後學習時數
 
Office Hours
 
參考書目
 
指定閱讀
 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
期中考 
20% 
 
2. 
期末考 
20% 
 
3. 
作業 
20% 
 
4. 
報告 
20% 
 
5. 
出席 
20% 
 
 
課程進度
週次
日期
單元主題