課程資訊
課程名稱
功能性Non-Coding RNA新知
Frontiers in Functional Non-Coding RNAs 
開課學期
97-2 
授課對象
生物資源暨農學院  生物科技研究所  
授課教師
林劭品 
課號
Biot8014 
課程識別碼
642ED0160 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期三7,8(14:20~16:20) 
上課地點
生技所410 
備註
本課程以英語授課。與林詩舜合開
限博士班
總人數上限:10人 
 
課程簡介影片
 
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課程概述

It is now clear that lots of non-coding RNAs in the genome are functional and very powerful in regulating gene activities and developmental process.
Depends on the background of the students, around 1/3 of the lectures will be given by the instructor for introducing basic concepts in non-coding RNA regulated gene silencing, including the post-transcriptional regulation by siRNA, microRNA and reproductive organ specific piRNAs. These will cover the physiological process including Genomic Imprinting, Sex Chromosome Compensation, Silencing of Endogenous Retrotransposons and Stem Cell Biology. In addition, the involvement of non-coding RNA related Regulatory Mechanisms in Carcinogenesis will be discussed.
For the rest of the classes, students will be assigned the most updated original research papers and conference articles as well as the milestone publications. They will be randomly divided into 2 groups for each assignment. One group will be presenting the articles and students in the other group are expected to challenge the papers from the experimental design, the methodology to the interpretation of the data. Students in the 1st group should defend for the papers as if it’s their manuscript. Students from the 2nd group should also provide constructive advice as how to improve the manuscript so that it can be published in a higher impact journal. 

課程目標
On top of learning the basic concepts of non-coding RNA related Regulatory Mechanisms, keeping abreast of the most updated research internationally, students are expected to develop the ability to critically evaluate and interpret published research articles. In addition, they will learn the art of reviewing as well as defending a manuscript for publication. 
課程要求
Preferably having studied one of the following subjects: (Introductory) Epigenetics, Special Topics in Reprogramming, Genetics and Epigenetics in Germ and Stem Cells 
預期每週課後學習時數
 
Office Hours
 
參考書目
Updated journal articles and reviews; “Epigenetics: Concepts, Theories, Paradigms and Mechanisms” and “Stem cell and Regenerative Medicine” CD-Roms (A Henry StewartTalks Series in the Life Sciences), National and International Conference Abstracts and Papers. Unpublished data. 
指定閱讀
 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
無資料