1.選讀 Epigenomics 相關領域最新發表文獻與近期研討會討論議題。包含DNA甲基化、染色質調控、功能性 non-coding RNA對於細胞生理與病理之影響。
We will select the most updated literature with significant breakthroughs in different layers of epigenomic regulatory machineries. These includes the studies on how DNA methylation, chromatin modification and remodeling, functional non-coding RNA machineries that coordinately regulate epigenetic landscape and this gene expression pattern and cell fate. We will also discuss wet bench experimental design and bioinformatic analytical tools for analyzing and consolidating DNA methylome, transcriptome, small RNA analysis, lincRNA and native elongating RNA-seq and Chromatin-ImmunoPrecipitation (ChIP)-seq, ChIRP (Chromatin Isolation by RNA purification) and RNA-IP-seq datasets. Contents of most recent international conferences, sometimes including unpublished data, will also be discussed.
We will also periodically invite local and international experts to join our course. One week before their seminar, we will discuss their published research article to help students prepared for the actual interaction with world experts in the field.