課程名稱 |
細胞再程序化專論 Special Topic in Reprogramming |
開課學期 |
99-2 |
授課對象 |
學程 幹細胞與再生醫學學程 |
授課教師 |
林劭品 |
課號 |
Biot5002 |
課程識別碼 |
642EU0040 |
班次 |
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學分 |
2 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期三5,6(12:20~14:10) |
上課地點 |
生技所415 |
備註 |
本課程以英語授課。 限學士班三年級以上 總人數上限:15人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/992reprogramming_1 |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
Depends on the background of the students, 1/3 to 1/2 of the lectures will be given by the instructor for introducing basic concepts in all aspects of cellular reprogramming, including somatic cell nuclear transfer, stem cell differentiation and the application in regenerative medicine. For the rest of the classes, students will be assigned the most updated original research papers as well as the milestone publications. They will be randomly divided into 2 groups for each assignment. One group will be presenting the articles and students in the other group are expected to challenge the papers from the experimental design, the methodology to the interpretation of the data. Students in the 1st group should defend for the papers as if it’s their manuscript. Students from the 2nd group should also provide constructive advice as how to improve the manuscript so that it can be published in a higher impact journal. |
課程目標 |
On top of learning the basic concepts of epigenetics and reprogramming, students are expected to develop the ability to critically evaluate and interpret published research articles. In addition, they will learn the art of reviewing as well as defending a manuscript for publication. |
課程要求 |
Preferably having backgrounds in one of the following subjects: Biochemistry, Cell Biology, Genetics, Molecular Biology or Epigenetics |
預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
Updated journal articles and reviews; “Epigenetics: Concepts, Theories, Paradigms and Mechanisms” and “Stem cell and Regenerative Medicine” CD-Roms (A Henry StewartTalks Series in the Life Sciences) |
評量方式 (僅供參考) |
No. |
項目 |
百分比 |
說明 |
1. |
Open book midterm exam |
30% |
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2. |
Class participation |
10% |
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3. |
Oral presentation |
30% |
1. People from the same group share the same marks
2. 15% for the group presentation
3. 15% for the group discussion when other groups present |
4. |
Final Report |
30% |
A "mini-review" or "news and views" format,with text of less than 3 pages, excluding figures and references |
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週次 |
日期 |
單元主題 |
第1週 |
2/23 |
林劭品
Introduction and overview of Epignetics and Potency |
第2週 |
3/02 |
林劭品
Physiological transgenerational reprogramming in the germ line (I): genomic imprinting and retrotransposon silencing |
第3週 |
3/09 |
林劭品
Physiological transgenerational reprogramming in the germ line (II): X chromosome inactivation and reactivation |
第4週 |
3/16 |
林詩舜,廖虹富,林劭品
DNA methylation and demethylation |
第5週 |
3/23 |
林劭品 Discussion of Prof. Fisher's publications//
3/24 Robert Fisher: Genomic imprinting in plants |
第6週 |
3/30 |
林劭品
Overview of artificially induced programming and reprogramming |
第7週 |
4/06 |
溫書假 |
第8週 |
4/13 |
13:00-14:50 中研院分生所 109討論室
陳倩瑜、蔡懷寬
Systems biology for studying gene regulation
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第9週 |
4/20 |
13:00-14:50 中研院分生所 109討論室
陳倩瑜、蔡懷寬
Systems biology for studying gene regulation //
Open Book Mid-term Exam |
第10週 |
4/27 |
Prof. 宋麗英
Nuclear Reprogramming |
第11週 |
5/04 |
Prof. 郭紘志
The understanding of pluripotency regulation and their implication for in vitro reprogramming |
第12週 |
5/11 |
Prof. 朱家瑩
MicroRNAs and translational repression |
第13週 |
5/18 |
Prof. 黃彥華
Germ line stem cells |
第14週 |
5/25 |
Students' show time (I)//
5/27 1:30-3:00pm 台大生科館 4B教室
Murray Grant, University of Exeter, UK
Systems Biology for Host-pathogen interactions and Immunity
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第15週 |
6/01 |
Students' show time (II)//
6/3 1:30-3:00pm 台大生科館 4B教室
Shoichiro Kurata , Tohoku University, Japan
Systems Biology for Host-pathogen interactions and Immunity |
第16週 |
6/08 |
Students' show time (III) |
第17週 |
6/15 |
Summary, discussion and preparation for final report |
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