課程名稱 |
配子與幹細胞之上位遺傳學 GENETICS AND EPIGENETICS IN GERM AND STEM CELLS |
開課學期 |
97-2 |
授課對象 |
生物資源暨農學院 生物科技研究所 |
授課教師 |
林劭品 |
課號 |
Biot5005 |
課程識別碼 |
642EU0070 |
班次 |
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學分 |
2 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期三5,6(12:20~14:10) |
上課地點 |
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備註 |
本課程以英語授課。上課地點,本所R410 限學士班三年級以上 總人數上限:30人 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
Depends on the background of the students, 1/2 to 2/3 of the lectures will be given by the instructor for introducing basic concepts in Gametogenesis, Stem cells and the regulation by Genetics and Epigenetics. For the rest of the classes, students will be assigned the most updated original research papers as well as the milestone publications. They will be randomly divided into 2 groups for each assignment. One group will be presenting the articles and students in the other group are expected to challenge the papers from the experimental design, the methodology to the interpretation of the data. Students in the 1st group should defend for the papers as if it’s their manuscript. Students from the 2nd group should also provide constructive advice as how to improve the manuscript so that it can be published in a higher impact journal. |
課程目標 |
On top of learning the basic concepts of gametogenesis, epigenetics and reprogramming, students are expected to develop the ability to critically evaluate and interpret published research articles. In addition, they will learn the art of reviewing as well as defending a manuscript for publication. |
課程要求 |
Preferably having backgrounds in one of the following subjects: Biochemistry, Cell Biology, Genetics, Molecular Biology or Epigenetics |
預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
Updated journal articles and reviews; “Epigenetics: Concepts, Theories, Paradigms and Mechanisms” and “Stem cell and Regenerative Medicine” CD-Roms (A Henry StewartTalks Series in the Life Sciences) |
評量方式 (僅供參考) |
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週次 |
日期 |
單元主題 |
第1週 |
2/18 |
Introduction (Epigenetics, Stem cell, Germ cell) |
第2週 |
2/25 |
An overview of stem cell biology and germ cell development |
第3週 |
3/04 |
An introductions of epigenetic regulations: DNA methylation, Histone mofications, Non-coding RNAs (I) |
第4週 |
3/11 |
An introductions of epigenetic regulations: DNA methylation, Histone mofications, Non-coding RNAs (II) |
第5週 |
3/18 |
An introduction of epigenetic modification in stem cell: (I) Embryonic Stem Cell |
第6週 |
3/25 |
An introduction of epigenetic modification in stem cells: (I) Somatic Stem Cell |
第7週 |
4/01 |
An introduction of epigenetic modification in germline cell: (I) Specification and Reprogramming |
第8週 |
4/08 |
An introduction of epigenetic modification in germline cell: (II) Gamete Development (sperm and oocyte) |
第9週 |
4/15 |
Midterm |
第10週 |
4/22 |
Stem Cells: (I) differentiation (II) DNA methylation, histone modifications |
第11週 |
4/29 |
Stem Cells: (III) small RNAs (IV) bioinformatic tools |
第12週 |
5/06 |
Cancer Stem Cells: (I) an introductions of cancer biology (II) specific topic |
第13週 |
5/13 |
Germ Cells: (I) genomic and retrotransponson modifications |
第14週 |
5/20 |
Germ Cells: (II) the similiar regulations between germline cell and stem cells |
第15週 |
5/27 |
Specific topic: (I) iPS (II) Very small embryonic stem (VSEL) cell (III) virus silencing |
第16週 |
6/03 |
Discussion |
第17週 |
6/10 |
Discussion |
第18週 |
6/17 |
Final |
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