課程資訊
課程名稱
環境職業性肺病研究專題討論一
Environmental and Occupational Lung Diseases (I)(Ⅰ) 
開課學期
105-1 
授課對象
公共衛生學院  職業醫學與工業衛生研究所  
授課教師
楊孝友 
課號
OMIH5131 
課程識別碼
841 U5920 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期三6,7(13:20~15:10) 
上課地點
公衛207 
備註
總人數上限:12人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1051OMIH5131_1 
課程簡介影片
 
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課程概述

This class will systemically review breathomics papers, analyze breathomics data, and write a research proposal for an epidemiological study of occupational and environmental lung diseases. 

課程目標
1. To have the knowledge of breathomics
2. Be able to analyze breathomics data.
3. To complete a proposal for a research topic.
 
課程要求
待補 
預期每週課後學習時數
 
Office Hours
備註: 出席 25%、課堂討論 75% 
指定閱讀
待補 
參考書目
1. Anton Amann and David Smith. Volatile Biomarkers Non-Invasive Diagnosis in Physiology and Medicine, Oxford, UK: Elsevier; 2013. (ISBN: 978-0-444-62613-4)
2.賈偉:醫學代謝組學。第一版,上海:上海科學技術出版社,2011。(ISBN: 9787547804926) 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第1週
9/15  (1) Mathematical and Statistical Approaches for Interpreting Biomarker Compounds in Exhaled Human Breath
(2) Issues and Challenges in Human Breath Research  
第2週
9/22  (3) Real-Time Analysis of Exhaled Breath
(4) Physiological Modeling for Analysis of Exhaled Breath  
第3週
9/29  (5) The Analysis of Oral Air by Selected Ion Flow Tube Mass Spectrometry Using Indole and Methylindole as Examples
(6) Smokers Breath as Seen by Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry (PTR-TOF-MS)  
第4週
10/06  (7) Exhaled Breath Analysis in Occupational Medicine
(8) Volatile Organic Compounds in Human Breath: Biogenic Origin and Point-of-Care Analysis Approaches 
第5週
10/13  (9) Breath Analysis in Critically Ill Patients—Potential and
Limitations
(10) Analysis of Cancer Biomarkers in Exhaled Breath and Comparison with Sensory Indications by Dogs 
第6週
10/20  (11) Added Value with Extended NO Analysis
(12) Carbon Monoxide as an Exhaled Biomarker of Pulmonary Diseases 
第7週
10/27  (13) Exhaled Nitric Oxide in Clinical Practice: Recent Advances and New Challenges
(14) An Update on 13C-Breath Tests: The Transition to Acceptability into Clinical Practice 
第8週
11/03  (15) Sensors for Exhaled Gas Analysis: An Analytical Review
(16) Arrays of Nanomaterial-Based Sensors for Breath Testing  
第9週
11/10  Hand-on Exercise for Breathomics Data I  
第10週
11/17  (17) Smart Sensor Systems for Human Health Breath Monitoring Applications
(18) VOC Analysis by SIFT-MS, GC-MS, and Electronic Nose for Diagnosing and Monitoring Disease 
第11週
11/24  (19) Measurement of Biomarkers of Oxidative Stress and Airway Inflammation in Exhaled Breath Condensate: Methodology and Potential Applications in Patients with COPD and Healthy Smokers
(20) Particles in Exhaled Air—A Novel Method of Sampling Non-Volatiles in Exhaled Air 
第12週
12/01  (21) Challenges in the Investigation of Volatile
Disease Biomarkers in Urine
(22) Volatile Organic Compounds (VOCs) Found in Urine and Stool  
第13週
12/08  (23) Volatile Organic Compounds (VOCs) Released
by Pathogenic Microorganisms in vitro: Potential Breath Biomarkers for Early-Stage Diagnosis of Disease
(24) Potential Applications of Volatile Organic Compounds in Safety and Security 
第14週
12/15  Hand-on Exercise for Breathomics Data II  
第15週
12/22  Presentation of Proposal for Research Topic I  
第16週
12/29  Presentation of Proposal for Research Topic II  
第17週
1/05  Presentation of Proposal for Research Topic III  
第18週
1/12  Hand-on Exercise for Breathomics Data III