課程資訊
課程名稱
環境毒理學概論
PRINCIPLES OF ENVIRONMENTAL TOXICOLOGY 
開課學期
97-1 
授課對象
公共衛生學院  環境衛生研究所  
授課教師
林靖愉 
課號
EH5019 
課程識別碼
844EU1280 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期四5,6(12:20~14:10) 
上課地點
公衛210 
備註
本課程以英語授課。
總人數上限:27人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/971envtox_lin 
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課程概述

This is an elective course for students who are interested in environmental toxicology. The course first introduces the fundamental principles in the field of toxicology. Physicochemical properties of toxicants following the fate processes (absorption, distribution, metabolism, and elimination), toxicokinetics, and toxicodynamics will be presented. Factors affecting fate and response and mechanisms of toxic action will also be discussed within the course. The course will then introduce the fate of chemicals in the environment. Finally, modern techniques in studying toxicant metabolism and environmental toxicology will be discussed.  

課程目標
Principles of toxicology will be first introduced. Fate processes of toxicants in the body, toxicokinetics, toxicodynamics, and mechanism of toxic action will be presented. Fate of chemicals in environment will also be discussed. Students will learn the basic concepts of toxicology and study the whole picture of fate processes of chemicals in both the human body and environment. Students will also learn the advanced technology in toxicological studies. The ultimate goal of the course is to bring students interests in toxicology with abilities in problem solving.  
課程要求
The curse is offered in English. The prerequisite of this course is Organic Chemistry. Homework will be assigned. The course will include two midterm exams and one final exam. 
預期每週課後學習時數
 
Office Hours
另約時間 備註: by appointment  
參考書目
Casarett & Doull’s Toxicology – The Basic Science of Poisons by Curtis D.
Klaassen
Goodman & Gilman's The Pharmacological Basis of Therapeutics by Laurence L.
Brunton, John S. Lazo, and Keith L. Parker 
指定閱讀
 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第1週
09/18  Principles of toxicology 
第2週
09/25  Physicochemical properties of toxicants 
第3週
10/02  Fate processes in the body –absorption, distribution 
第4週
10/09  Fate processes in the body –metabolism, elimination 
第5週
10/16  TBA 
第6週
10/23  Midterm I 
第7週
10/30  Toxicokinetics, PBPK 
第8週
11/06  Toxicodynamics 
第9週
11/13  Factors affecting fate and response  
第10週
11/20  Mechanisms of toxic action 
第11週
11/27  Mechanisms of toxic action 
第12週
12/04  Midterm exam II 
第13週
12/11  Fate processes in environment - chemical principles 
第14週
12/18  Fate processes in environment - biological applications 
第15週
12/25  Modern techniques in toxicant metabolism 
第16週
01/01  New Year holiday 
第17週
01/08  Toxicogenomic technologies 
第18週
01/15  Final exam