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課程名稱 |
基因體研究特論
Special Topics in Genomic Studies |
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開課學期 |
103-1 |
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授課對象 |
公共衛生學院 流預所流行病學組 |
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授課教師 |
郭柏秀 |
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課號 |
EPM7181 |
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課程識別碼 |
849 M0750 |
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班次 |
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學分 |
2 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期三3,4(10:20~12:10) |
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上課地點 |
公衛209 |
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備註 |
總人數上限：15人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1031EPM7181_ |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
The major goal of this course is to learn the concepts, new methods and findings of a wide-range of topics in genomic studies through reading and discussion of original articles. Selected articles of each topic have a major theme and involved various issues commonly encountered in genomic studies. Course will begin with an introductory lecture to point out important issues. Students are expected to read assigned articles in advance and discuss the designated questions during class. |
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課程目標 |
1. To learn the concepts, new methods and findings of a wide-range of topics in genomic studies.
2. To learn how to read critically original articles in genomic studies.
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課程要求 |
[需先修習過遺傳流行病學原理(課號849M0330)，或其他授課教師認可之先修遺傳學相關課程]
Class participation: including presentation (taking turns in different sessions) and discussion.
Assignments: oral or written discussion about the designated questions listed in each session.
Written final report: choose a topic and describe concisely the design, main findings, unsolved problems, and future directions of studies in the field.
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預期每週課後學習時數 |
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Office Hours |
另約時間 |
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指定閱讀 |
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參考書目 |
Human Genome Epidemiology, 2nd Edition
Building the evidence for using genetic information to improve health and
prevent disease.
Edited by
Muin Khoury, Sara Bedrosian, Marta Gwinn, Julian Higgins, John Ioannidis,
and Julian Little |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
Class participation |
40% |
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2. |
Class assignments |
30% |
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3. |
Written final report |
30% |
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週次 |
日期 |
單元主題 |
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第1週 |
9/17 |
Course introduction and summary of genetic epidemiology |
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第2週 |
9/24 |
Replication and Heterogeneity |
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第3週 |
10/01 |
Quality control and Genomic control/ population stratification |
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第4週 |
10/08 |
Implementation of genome-wide association studies |
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第5週 |
10/15 |
Genomic landscape |
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第6週 |
10/22 |
CV/RV-Missing heritability |
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第7週 |
10/29 |
Copy-number variation |
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第8週 |
11/05 |
Public Health Applications of Genomics |
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第9週 |
11/12 |
Incorporating interactions |
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第10週 |
11/19 |
Epigenetics |
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第11週 |
11/26 |
Omic Technologies and Bioinformatics |
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第12週 |
12/03 |
DNA Sequencing |
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第13週 |
12/10 |
Pathway-based analysis |
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第14週 |
12/17 |
Pharmacogenomics |
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第15週 |
12/24 |
Genome Medicine/Data sharing |
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第16週 |
12/31 |
Final report |
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第17週 |
1/07 |
Final report |