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課程名稱 |
存活分析
Survival Analysis |
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開課學期 |
108-2 |
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授課對象 |
學程 生物統計學程 |
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授課教師 |
張淑惠 |
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課號 |
EPM7183 |
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課程識別碼 |
849 M0780 |
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班次 |
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學分 |
3.0 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期一6,7,8(13:20~16:20) |
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上課地點 |
公衛212 |
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備註 |
106以前生統組碩士班三科擇一之必修。其他系所組學生欲選修者應經授課教師同意。
總人數上限：25人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1082EPM7183_ |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
存活分析所用到的基本統計觀念與統計分析技巧，內容包括臨床存活資料之介紹、存活函數估計方法、多組樣本比較與存活資料之迴歸模式與分析。
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課程目標 |
使修課者了解存活資料之基礎統計分析概念與技巧，與在臨床試驗與醫學研究的應用。
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課程要求 |
無 |
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預期每週課後學習時數 |
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Office Hours |
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參考書目 |
1.Kleinbaum and Klein (2012) Survival Analysis-A Self-Learning Text,Third
Edition,Springer
圖書館電子檔網址:
http://tulips.ntu.edu.tw/search*cht/X?SEARCH=(Kleinbaum%20and%20Klein%20(2012)%
20Survival%20Analysis-A%20Self-Learning%20Text)
2. Collett, D (2003) Modelling Survival Data in Medical Research, 2nd
Edition , Chapman & Hall/CRC
3. Marubini, E, Valsecchi MG (1995) Analysing Survival Data from Clinical
Trials and Observational Studies. John Wiley and Sons
4. Kalbfleisch, JD and Prentice, RL (2002) The Statistical Analysis of
Failure Time Data, 2nd Edition , John Wiley and Sons
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指定閱讀 |
待補 |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
mid-term exam |
35% |
in-class open-book exam |
2. |
exercises and in-class performance |
30% |
group and individual exercises/quiz
In-class discussion and working in groups are encouraged.
Still, students must write up own assignments individually. |
3. |
Oral and written report |
35% |
The report will contain one paper reading and a data analysis for a new data set or for applying new models or methods to an existing data set.
Discussion and participation for other oral reports will be encouraged and counted in the grade. |
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週次 |
日期 |
單元主題 |
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第01週 |
03/02 |
Introduction to Survival Analysis |
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第02週 |
03/09 |
Kaplan-Meier Survival Curves |
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第03週 |
03/16 |
Log-Rank Test |
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第04週 |
03/23 |
The Cox Proportional Hazards Model (1) |
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第05週 |
03/30 |
The Cox Proportional Hazards Model (2): Inferences and Stratification |
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第06週 |
04/06 |
The Cox Proportional Hazards Model (3): Evaluating the PH Assumption |
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第07週 |
04/13 |
Extension of the Cox Proportional Hazards Model: Time-Dependent Variables |
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第08週 |
04/20 |
Sampling Design Issues in Survival Analysis |
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第09週 |
04/27 |
Parametric Models for Survival Data (*announce the arrangement and order of speakers and discussants) |
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第10週 |
05/04 |
Competing Risks Data Analysis (*upload reported papers) |
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第11週 |
05/11 |
Frailty Models in Survival Analysis |
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第12週 |
05/18 |
Advanced topics ( Parametric Frailty Models/ Recurrent Event Data Analysis) |
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第13週 |
05/25 |
In-class written exam |
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第14週 |
06/01 |
Oral Report (+1 hour) |
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第15週 |
06/08 |
Oral Report (+1 hour) |
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第16週 |
06/15 |
Oral Report (+1 hour) |
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第17週 |
06/22 |
Final report |
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