課程資訊
課程名稱
傳染病流行病學數理模式
Modeling of Infectious Diseases Epidemiology 
開課學期
100-2 
授課對象
學程  傳染病學學程  
授課教師
方啟泰 
課號
EPM5044 
課程識別碼
849 U0150 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期三7,8(14:20~16:20) 
上課地點
公衛213 
備註
與溫在弘、林先和合開
總人數上限:25人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1002idepimodeling 
課程簡介影片
 
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課程概述

This course is intended for undergraduate and graduate students who have the desire to understand the basic concepts of mathematical modeling and its applications to the epidemiological study of infectious diseases. The course will provide students to discover how mathematical concepts help us understand the spread of infectious pathogens through dynamic populations. Students will explore existing mathematical models in practical computer lab sessions, and also learn how to determine the key parameters involved in the spread of pathogens, the impact of changes in these parameters, and discuss the public health policy implications. Through discussions of published papers, students will learn how to critically evaluate a modeling paper, and how to communicate the modeling results with policy-makers.
 

課程目標
The course has two major objectives: (1) introduce basic principles of mathematical modeling methods and (2) emphasize the significance of simulation and modeling to the study of infectious disease epidemiology. 
課程要求
Weekly readings, written assignments and participation in class discussion and computer lab. There is a take-home mid-term exam for evaluating students the ability of implementing a disease transmission model. Students also need to complete term project addressing mathematical or computer modeling in one of infectious diseases of their choice.  
預期每週課後學習時數
 
Office Hours
 
參考書目
指定閱讀
Keeling, M.J. and Rohani, P. (2008) Modeling Infectious Diseases in Humans and
Animals. Princeton University Press.

參考書目
1. Anderson, R. M. and May, R. M. (1992) Infectious Diseases of Humans:
Dynamics and Control, Oxford University Press
2. Sattenspiel, L (2009), The Geographic Spread of Infectious Diseases: Models
and Applications, Princeton University Press
3. Hannon, B and Ruth, M (2009), Dynamic Modeling of Diseases and Pests,
Springer
 
指定閱讀
 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
Mid-Term Presentation 
30% 
 
2. 
Homework 
40% 
 
3. 
Term Exam Presentation  
30% 
 
 
課程進度
週次
日期
單元主題
第1週
02/22  Introduction to Modeling in Infectious Diseases Epidemiology(溫在弘/方啟泰) 
第2週
02/29  SIR Model and R0(林先和) 
第3週
03/07  Simulating SIR Epidemics with Berkeley Madonna(林先和) 
第4週
03/14  Latent Period and Carrier State: SEIR Model(林先和) 
第5週
03/21  Modeling disease with complex natural history: tuberculosis as an example(林先和) 
第6週
03/28  Parameter Estimation and Sensitivity Analyses(林先和) 
第7週
04/04  溫書假 
第8週
04/11  Mid-term Presentation(林先和) 
第9週
04/18  Simulating SIR and SEIR Epidemics with STELLA(溫在弘) 
第10週
04/25  Infection-related Mortality (SI Model) and Without/Waning Immunity (SIS and SIRS Model)(溫在弘/方啟泰) 
第11週
05/02  Modeling Risk-Structure(溫在弘/方啟泰) 
第12週
05/09  Modeling Age-Structure(溫在弘/方啟泰) 
第13週
05/16  Stochastic Dynamics(溫在弘/方啟泰) 
第14週
05/23  Invited Special Lecture: Spatiotemporal Modeling of Infectious Disease Dynamics(台大生工系 余化龍副教授) 
第15週
05/30  Controlling Infectious Diseases: Vaccination and Isolation(方啟泰) 
第16週
06/06  Term Exam (Take Home) 
第17週
06/13  Term Exam Presentation(溫在弘/方啟泰) 
第18週
06/20  Term Exam Presentation(溫在弘/方啟泰)