課程資訊
課程名稱
 系統回顧與統合分析
Systematic Review and Meta-analysis 
開課學期
 104-2 
授課對象
 共同教育中心  統計碩士學位學程  
授課教師
 林先和 
課號
 EPM5053 
課程識別碼
 849EU0240 
班次
  
學分
 2 
全/半年
 半年 
必/選修
 選修 
上課時間
 星期二6,7(13:20~15:10) 
上課地點
 公衛212 
備註
 本課程以英語授課。本課程為學程甲組(生醫生物組)選修課程之一。與李建璋、陳建煒、杜裕康合開
總人數上限：52人 
Ceiba 課程網頁
 http://ceiba.ntu.edu.tw/1042EPM5053_2016 
課程簡介影片
 
核心能力關聯
 本課程尚未建立核心能力關連
課程大綱
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課程概述

This course will introduce students to the principles in conducting a systematic and quantitative review of randomised controlled trials and observational studies. The course will be structured by the critical steps in conducting a systematic review and meta-analysis, with particular emphasis on common pitfalls when doing such an analysis. A series of case studies of important public health and medical issues will be used as in-class examples. The course consists of lectures, computer labs using common software packages for meta-analysis, and a final group project resulting in a draft meta-analysis paper. 

課程目標
 The goal of the course is to provide the students the general framework of conducting a systematic review and meta-analysis. At the end of the course the students are expected to be able to read and critically appraise the literature of systematic review and meta-analysis and to conduct his or her own meta-analysis. 
課程要求
 The students are expected to have taken introductory-level courses of epidemiology and biostatistics. The final group project (with a group size of 2~4) will be a meta-analysis report that can be submitted for publication after further revision. 
預期每週課後學習時數
  
Office Hours
  
指定閱讀
 The readings of each lecture will be posted on the course schedule and uploaded to CEIBA.  
參考書目
 1. Introduction to Meta-Analysis (Statistics in Practice), Michael Borenstein,
Larry Hedges, Julian Higgins, and Hannah Rothstein. Wiley, 2009.
2. Systematic Reviews in Health Care: Meta-analysis in Context, 2nd Edition,
Matthias Egger, George Davey Smith, and Douglas Altman, eds. BMJ Books, 2001.
(available as an eBook at NTU Library)
3. Cochrane Handbook for Systematic Reviews of Interventions, Julian Higgins,
Sally Green, eds. Wiley-Blackwell, 2008. (available online at
http://www.cochrane-handbook.org/) 
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 Class participation 
20% 
  
2. 
 Mid-term presentation 
20% 
  
3. 
 Final group project 
60% 
  
 
課程進度
週次
日期
單元主題
第1週
 02/23  Introduction and course overview
1. Egger Chapters 1 & 2
2. Colditz GA, et al. Efficacy of BCG Vaccine in the Prevention of Tuberculosis: Meta-analysis of the published literature. JAMA 1994;271:698-702. 
第2週
 03/01  Selecting studies and extracting data (Higgins Chapter 7)  
第3週
 03/08  1. Literature review and searching methods (呂宜欣)
2. Introduction to reference management software: EndNote (姚建中)
Group list due 
第4週
 03/15  Assessing the quality of included studies
Higgins Chapter 8 & 13 (up until 13.5 Assessing risk of bias in non-randomized studies) Homework II due 
第5週
 03/22  1. Fixed-effect and random-effects models
2. Assessing heterogeneity
(Borenstein Chapters 10-13, 16 or Higgins Chapter 9, Egger Chapters 9 and 15)  
第6週
 03/29  Lab I Group project-Protocol due 
第7週
 04/05  兒童節遇例假日補假 
第8週
 04/12  Subgroup analysis and Meta-regression (Borenstein Chapters 19-21 or Higgins Chapter 9, Egger Chapter 8) In-class paper discussion 
第9週
 04/19  Lab II 
第10週
 04/26  Student presentation: research topic, search protocol, final search results, and data extraction form 
第11週
 05/03  Publication bias 
第12週
 05/10  Meta-analysis of diagnostic tools(Chien-Chang Lee) 
第13週
 05/17  Lab III 
第14週
 05/24  Interpreting the results and reporting systematic review and meta-analysis
Higgins Chapter 11& 12, PRISMA (PLoS Med 2009)
 
第15週
 05/31  Using meta-analysis for safety evaluation (Arnold K Chan)  
第16週
 06/07  Introduction to network meta-analysis(Yu-Kang Tu) 
第17週
 06/14  Group project presentation 
第18週
 06/21  Group project presentation