課程資訊
課程名稱
生醫分子影像導論
FUNDAMENTALS OF MOLECULAR IMAGING 
開課學期
98-2 
授課對象
電機資訊學院  電機工程學研究所  
授課教師
陳志宏 
課號
EE5124 
課程識別碼
921 U7800 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期二2,3,4(9:10~12:10) 
上課地點
電二102 
備註
與董成淵、張富雄、孫啟光、李百祺合開
總人數上限:35人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/982molecular 
課程簡介影片
 
核心能力關聯
本課程尚未建立核心能力關連
課程大綱
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課程概述

Molecular imaging is the technology that successfully combined molecular biology and clinical medicine, and it will be one of potential fields of medicine in the future. Generally, there are three advantages on molecular imaging research: first, it can transform complicated processes of gene expression and signal transduction into image visually, and that one can realize the possible disease mechanism and features; second, it’s able to find early on molecular variations of disease and the process of pathology; last, it can in vivo observe continuously the mechanism and effect on drug or gene therapy. Molecular imaging integrated molecular biochemistry, data processing, nanotechnology and imaging processing, and then it possesses the properties of high specificity, high sensitivity and ultra-high spatial resolution. 

課程目標
Molecular imaging is the technology that successfully combined molecular biology and clinical medicine, and it will be one of potential fields of medicine in the future. Generally, there are three advantages on molecular imaging research: first, it can transform complicated processes of gene expression and signal transduction into image visually, and that one can realize the possible disease mechanism and features; second, it’s able to find early on molecular variations of disease and the process of pathology; last, it can in vivo observe continuously the mechanism and effect on drug or gene therapy. Molecular imaging integrated molecular biochemistry, data processing, nanotechnology and imaging processing, and then it possesses the properties of high specificity, high sensitivity and ultra-high spatial resolution. 
課程要求
Homework 40%
Midterm Exam 20%
Final project report 20%
Final Exam 20%
 
預期每週課後學習時數
 
Office Hours
 
參考書目
1. Michel M.J. Modo et al., Molecular and Cellular MR Imaging, CRC, 2007.
2. Spencer L. Shorte er al., Imaging Cellular and Molecular Biological Functions (Principles and Practice), Springer; 1st edition, 2007
3. M. Rudin, Molecular Imaging: principles and applications in biomedical research, Hackensack, NJ: Imperial College Press, 2005.
4. M. Schwaiger et al, From morphological imaging to molecular targeting: implications to preclinical development, Berlin; New York: Springer, 2004.
5. A. A. Bogdanov et al, Molecular Imaging: An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy, Springer, 2005.
 
指定閱讀
There is not a single up-to-date quantitative book containing most of the materials in this course, but several reference books are recommended in appendix I. First three books in the list are all good choices to keep. 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第1週
2/23  Fundamentals of Medical Imaging 
第2週
3/02  Optical Molecular Imaging (1) 
第3週
3/09  Optical Molecular Imaging (2) 
第4週
3/16  Fundamentals of Molecular Biology (1) 
第5週
3/23  Fundamentals of Molecular Biology (2) 
第6週
3/30  Fundamentals of Molecular Biology (3) 
第7週
4/06  溫書假 
第8週
4/13  Molecular Imaging of Probe Design 
第9週
4/20  Mid Term Exam (20%) 
第10週
4/27  Ultrasonic Molecular Imaging (1) 
第11週
5/04  Ultrasonic Molecular Imaging (2)-Photoacoustic Molecular Imaging 
第12週
5/11  MR Fundamentals/ MR Molecular Imaging (1) 
第13週
5/18  MR Molecular Imaging (2) 
第14週
5/25  Medical Imaging analysis 
第15週
6/01  The Application of Molecular Imaging-Molecular Imaging of Nuclear Medicine 
第16週
6/08  邀請成佳憲醫師演講 Molecular Imaging in Oncology 
第17週
6/15  Final Report  
第18週
6/22  Final Exam(20%)