This course covers the advanced topics in computer architecture design, including techniques to exploit instruction-level scheduling, memory hierarchy, multicore architecture, GPU/ML accelerator design, low-power architecture and storage system. We will also embed a few lab modules in this course for application accelerator with High-level-Synthesis (HLS). The objective of these lab modules is to empower software designers to develop application accelerators with a high-level language, e.g. C/C++.