課程名稱 |
系統代謝學 Systems Analysis on Metabolomics |
開課學期 |
101-2 |
授課對象 |
電機資訊學院 資訊工程學研究所 |
授課教師 |
曾宇鳳 |
課號 |
CSIE5153 |
課程識別碼 |
922EU3820 |
班次 |
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學分 |
3 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期四5,6,7(12:20~15:10) |
上課地點 |
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備註 |
初選不開放。本課程以英語授課。需修習過「代謝體學」。上課地點:資540.與郭錦樺合開 總人數上限:30人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1012sysmeta |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
Metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind" - specifically, the study of their small-molecule metabolite profiles. The metabolome represents the collection of all metabolites in a biological organism, which are the end products of its gene expression. Thus, while mRNA gene expression data and proteomic analyses do not tell the whole story of what might be happening in a cell/organ/organism, metabolic profiling can give an instantaneous snapshot of the physiology of that cell/organ/organism. |
課程目標 |
Metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind" - specifically, the study of their small-molecule metabolite profiles. The metabolome represents the collection of all metabolites in a biological organism, which are the end products of its gene expression. Thus, while mRNA gene expression data and proteomic analyses do not tell the whole story of what might be happening in a cell/organ/organism, metabolic profiling can give an instantaneous snapshot of the physiology of that cell/organ/organism. |
課程要求 |
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預期每週課後學習時數 |
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Office Hours |
另約時間 |
指定閱讀 |
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參考書目 |
1. Silas G. Villas-Boas, Jens Nielsen, Jorn Smedsgaard, Michael A. E. Hansen,
Ute Roessner-Tunali, Metabolome Analysis: An Introduction, Wiley, 2007
2. Seetharaman Vaidyanathan and George G. Harrigan, Metabolome analyses:
Strategies for system biology, Springer Science, 2005
3. Howard Mark and Jerry Workman, Jr., 2007, Chemometrics in Spectroscopy,
Academic Press
4. M. Tomita and T. Nishioka, Metabolomics: The Frontier of Systems Biology,
Springer Tokyo, 2005
5. William J. Griffiths, Metabolomics, Metabonomics and Metabolite Profiling,
Baker & Taylor, 2008
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評量方式 (僅供參考) |
No. |
項目 |
百分比 |
說明 |
1. |
Exam (Midterm and Final) |
80% |
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2. |
Paper presentation |
20% |
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週次 |
日期 |
單元主題 |
第1週 |
02/21 |
Introduction to Metabolomics |
第2週 |
02/28 |
Holiday (228和平紀念日) |
第3週 |
03/07 |
Sampling and Sample Preparation |
第4週 |
03/12 |
Workshop of NMR Metabolomics in Academia Sinica |
第5週 |
03/21 |
Principles of Chromatography |
第6週 |
03/28 |
Mass Spectrometry |
第7週 |
04/04 |
Holiday (婦幼節暨民族掃墓節) |
第8週 |
04/11 |
LC-MS and GC-MS |
第9週 |
04/18 |
Midterm |
第10週 |
04/25 |
Mass Spectrum |
第11週 |
05/02 |
Capillary electrophoresis |
第12週 |
05/09 |
Nuclear Magnetic Resonance Spectrum |
第13週 |
05/16 |
1D and 2D NMR Spectroscopy: From Metabolic Fingerprinting to Profiling |
第14週 |
05/23 |
New Developments in Multi-dimensional Mass Spectrometry Based Shotgun Lipidomics |
第15週 |
05/30 |
Neutral Lipidomics and Mass Spectrometry |
第16週 |
06/06 |
Bioinformatics of Lipids |
第17週 |
06/13 |
Metabonomics and Global Systems Biology |
第18週 |
06/20 |
Final Exam |
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