課程資訊
課程名稱
光學診斷技術
Optical Techniques in Diagnosis 
開課學期
105-2 
授課對象
電機資訊學院  電機工程學研究所  
授課教師
宋孔彬 
課號
BEBI7004 
課程識別碼
945 M2900 
班次
 
學分
3.0 
全/半年
半年 
必/選修
選修 
上課時間
星期二2,3,4(9:10~12:10) 
上課地點
明達303 
備註
總人數限14人。
總人數上限:14人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1052BEBI7004_ 
課程簡介影片
 
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課程概述

Biomedical optics has been increasingly applied to the screening, surveillance and diagnosis of diseases, as well as the non-invasive monitoring of physiological status of tissue/organs in vivo. The interaction between light and biological tissue involves mainly scattering and absorption, which can be modeled analytically with the framework of radiative transport equation or numerically with the Monte Carlo method. With sufficient understanding and appropriate modeling of light-tissue interactions, the clinically relevant and useful information can be extracted from optical signals measured from tissue. The following techniques will be reviewed:
1. Diffuse reflectance spectroscopy
2. Fluorescence spectroscopy
3. Functional near-infrared spectroscopy and tomography
4. Single(few) scattering spectroscopy
5. Raman scattering spectroscopy
Other optical techniques related to non-invasive diagnosis will be reviewed by the students (topics chosen by the students). Techniques that use only ballistic photons to provide signals (e.g. confocal microscopy and non-linear microscopy) are not reviewed in this course. 

課程目標
To obtain the fundamental knowledge and skills for the analysis and interpretation of data measured from tissue, the following steps will be employed:
1. The principle of light propagation in soft tissue will be introduced.
2. The students will learn the practical use of the Monte Carlo method to numerically simulate light propagation in tissue.
3. The students will review the literature on selected optical techniques that can be used to aid the non-invasive diagnosis of disease or monitoring of physiological status.
4. Students will get hands-on experience with Monte Carlo simulations by working on a term project with a topic related to optical diagnostic techniques. 
課程要求
1. Homework (individual)
Each student will develop a computer program using the Monte Carlo method to simulate propagation of photons in biological tissue. Eight sets of computer assignments will be given to gradually guide the students through the model development process. Basic programming ability or acquaintance with Matlab is required.
2. Literature review (individual)
To gain a more in-depth understanding of selected techniques, students are required to pick a specific topic, study related literature, and make an oral presentation to introduce the selected topic.
3. Term project (two students/group)
Students will apply the simulation method they have learned in class to improve the data interpretation/analysis or experimental design, or to address a specific question related to optical diagnosis/monitoring of disease/physiology. 
預期每週課後學習時數
 
Office Hours
另約時間 
參考書目
1. "Biomedical Optics: Principles and Imaging", by Lihong V. Wang and Hsin-i Wu. Wiley-Interscience, 2007.
2. "Tissue Optics: light scattering methods and instruments for medical diagnosis”, by Valery Tuchin. Bellingham, Washington: SPIE Press, 2007.
3. "Handbook of Biomedical Optics", edited by David A. Boas, Constantinos Pitris, Nimmi Ramanujam. CRC Press, 2011.
4. "Optical-Thermal Response of Laser-irradiated Tissue", edited by Ashley J. Welch and Martin J.C. van Gemert. New York: Plenum Press, 1995.
5. "Biomedical Photonics Handbook", edited by Tuan Vo-Dinh. CRC Press, 2003.  
指定閱讀
待補 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
Computer Homework 
40% 
 
2. 
Term project 
35% 
2 students per group 
3. 
Term project proposal 
10% 
 
4. 
Literature review 
15% 
 
 
課程進度
週次
日期
單元主題
第1週
2/21  Class overview, light/tissue interaction 
第2週
2/28  和平紀念日 - 停課 
第3週
3/07  Elastic scattering, Monte Carlo simulation I 
第4週
3/14  Monte Carlo simulation II 
第5週
3/21  Radiative transport equation 
第6週
3/28  Radiative transport equation and diffusion approximation 
第7週
4/04  民族掃墓節 - 停課 
第8週
4/11  Monte Carlo simulation III 
第9週
4/18  Literature review 
第10週
4/25  Monte Carlo simulation IV 
第11週
5/02  Monte Carlo simulation V 
第12週
5/09  Diffuse reflectance spectroscopy 
第13週
5/16  Oral presentation - term project discussion 
第14週
5/23  Probe geometry considerations
Fluorescence spectroscopy, Raman scattering spectroscopy 
第15週
5/30  端午節 - 停課 
第16週
6/06  Oral presentation - term project proposal 
第17週
6/13  Near-infrared spectroscopy, diffuse optical tomography