課程資訊
課程名稱
光學診斷技術
Optical Techniques in Diagnosis 
開課學期
108-2 
授課對象
電機資訊學院  電機工程學研究所  
授課教師
宋孔彬 
課號
BEBI7004 
課程識別碼
945EM2900 
班次
 
學分
3.0 
全/半年
半年 
必/選修
選修 
上課時間
星期五2,3,4(9:10~12:10) 
上課地點
明達303 
備註
本課程以英語授課。
總人數上限:14人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1082BEBI7004_OptDiag 
課程簡介影片
 
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課程概述

Biomedical optics has been increasingly applied to the screening, surveillance and diagnosis of diseases, as well as the non-invasive monitoring of physiological status of tissue/organs in vivo. The interaction between light and biological tissue involves mainly scattering and absorption, which can be modeled analytically with the framework of the Radiative Transport Equation (RTE) or numerically with the Monte Carlo method. With sufficient understanding and appropriate modeling of light-tissue interactions, the clinically relevant and useful information can be extracted from optical signals measured from tissue. The following techniques will be introduced:
1. Diffuse reflectance spectroscopy (DRS) and imaging
2. Near-infrared spectroscopy (NIRS) and tomography
3. Tissue oximetry using DRS or NIRS
4. Fluorescence spectroscopy
5. Single (few) scattering techniques
6. Raman scattering spectroscopy
Other optical techniques related to the non-invasive diagnosis or monitoring of physiological conditions will be reviewed by the students (topics chosen by the students). Note that techniques using only ballistic photons to provide signals (e.g. confocal microscopy and non-linear microscopy) are NOT covered in this course. 

課程目標
To obtain the fundamental knowledge and skills for the analysis and interpretation of data measured from tissue, the following steps will be employed:
1. The principle of light propagation in soft tissue will be introduced.
2. Students will learn the practical use of the Monte Carlo method to numerically simulate light propagation in soft tissues.
3. The students will review the literature on selected optical techniques that can be used to aid the non-invasive diagnosis of disease or monitoring of physiological status.
4. Students will get hands-on experience with Monte Carlo simulations or the RTE framework by working on a term project with a topic related to optical diagnostic techniques. 
課程要求
1. Homework (individual)
Each student will develop a computer program using the Monte Carlo method to simulate the propagation of photons in biological tissues. Eight sets of computer assignments will be given to gradually guide the students through the model development process. Basic programming ability or acquaintance with Matlab is required.
Alternatively, students can choose Track 2 in which they submit a progress report (with the same due data as the homework) instead of the computer homework.
2. Literature review (individual)
To gain a more in-depth understanding of selected techniques, students are required to pick a specific topic, study related literature, and make an oral presentation to introduce the selected topic. In addition, students are expected to participate in discussion.
3. Term project
Students will apply the simulation method they have learned in class to improve the data interpretation/analysis or experimental design, or to address a specific question related to optical diagnosis/monitoring of disease/physiology.
Students who choose Track 2 are required to prepare a draft for submitting to a conference or a journal. 
預期每週課後學習時數
 
Office Hours
另約時間 
參考書目
1. "Biomedical Optics: Principles and Imaging", by Lihong V. Wang and Hsin-i Wu. Wiley-Interscience, 2007.
2. "Tissue Optics: light scattering methods and instruments for medical diagnosis”, by Valery Tuchin. Bellingham, Washington: SPIE Press, 2007.
3. "Handbook of Biomedical Optics", edited by David A. Boas, Constantinos Pitris, Nimmi Ramanujam. CRC Press, 2011.
4. "Handbook of Optical Biomedical Diagnostics”, edited by Valery Tuchin. Bellingham, Washington: SPIE Press, 2016.
5. "Optical-Thermal Response of Laser-irradiated Tissue", edited by Ashley J. Welch and Martin J.C. van Gemert. New York: Plenum Press, 1995. 
指定閱讀
None 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
Literature review & presentation 
15% 
make an oral presentation to introduce an optical technique for in vivo tissue characterization 
2. 
Term project proposal 
15% 
oral presentation and written report; covers the objective, motivation, significance and literature review on prior methods 
3. 
Term project 
40% 
use homework or open-source software to do numerical simulation and analysis on a project related to optical diagnostic techniques 
4. 
Computer Homework 
30% 
8 sets of computer homework to develop a multi-layer Monte Carlo model of photon propagation in tissue 
 
課程進度
週次
日期
單元主題
第1週
03/06  Overview 
第2週
03/13  Elastic scattering 
第3週
03/20  Monte Carlo simulation I
# Homework #1 
第4週
03/27  Monte Carlo simulation II 
第5週
04/03  Holiday - no class
# Homework #2 
第6週
04/10  # Oral presentations - literature review
Radiative transport equation (RTE) 
第7週
04/17  RTE - analytical solution based on diffusion approximation
# Homework #3 
第8週
04/24  Monte Carlo simulation III 
第9週
05/01  Monte Carlo simulation IV
 
第10週
05/08  # Homework #4
Monte Carlo simulation V 
第11週
05/15  Diffuse reflectance spectroscopy
# Homework #5 
第12週
05/22  Diffuse Reflectance Spectroscopy
Monte Carlo simulation VI 
第13週
05/29  functional Near-Infrared Spectroscopy, Diffuse Optical Imaging/Tomography
# Homework #6 
第14週
06/05  Fluorescence spectroscopy, Raman scattering spectroscopy
 
第15週
06/12  Probe geometry considerations
# Homework #7 
第16週
06/19  # Oral presentations - Track 1 project proposal 
第17週
06/29  # term project mock report
# Homework #8 
第18週
07/03  # Term project report due