課程資訊
課程名稱
光學診斷技術
Optical Techniques in Diagnosis 
開課學期
107-2 
授課對象
電機資訊學院  生醫電子與資訊學研究所  
授課教師
宋孔彬 
課號
BEBI7004 
課程識別碼
945 M2900 
班次
 
學分
3.0 
全/半年
半年 
必/選修
選修 
上課時間
星期二2,3,4(9:10~12:10) 
上課地點
明達303 
備註
總人數上限:14人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1072BEBI7004_OptDiag 
課程簡介影片
 
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課程概述

Biomedical optics has been increasingly applied to the screening, surveillance and diagnosis of diseases, as well as the non-invasive monitoring of physiological status of tissue/organs in vivo. The interaction between light and biological tissue involves mainly scattering and absorption, which can be modeled analytically with the framework of the Radiative Transport Equation (RTE) or numerically with the Monte Carlo method. With sufficient understanding and appropriate modeling of light-tissue interactions, the clinically relevant and useful information can be extracted from optical signals measured from tissue. The following techniques will be introduced:
1. Diffuse reflectance spectroscopy (DRS) and imaging
2. Near-infrared spectroscopy (NIRS) and tomography
3. Tissue oximetry using DRS or NIRS
4. Fluorescence spectroscopy
5. Single (few) scattering techniques
6. Raman scattering spectroscopy
Other optical techniques related to the non-invasive diagnosis or monitoring of physiological conditions will be reviewed by the students (topics chosen by the students). Techniques that use only ballistic photons to provide signals (e.g. confocal microscopy and non-linear microscopy) are not covered in this course. 

課程目標
To obtain the fundamental knowledge and skills for the analysis and interpretation of data measured from tissue, the following steps will be employed:
1. The principle of light propagation in soft tissue will be introduced.
2. Students will learn the practical use of the Monte Carlo method to numerically simulate light propagation in soft tissues.
3. The students will review the literature on selected optical techniques that can be used to aid the non-invasive diagnosis of disease or monitoring of physiological status.
4. Students will get hands-on experience with Monte Carlo simulations by working on a term project with a topic related to optical diagnostic techniques. 
課程要求
1. Homework (individual)
Each student will develop a computer program using the Monte Carlo method to simulate propagation of photons in biological tissue. Eight sets of computer assignments will be given to gradually guide the students through the model development process. Basic programming ability or acquaintance with Matlab is required.
2. Literature review (individual)
To gain a more in-depth understanding of selected techniques, students are required to pick a specific topic, study related literature, and make an oral presentation to introduce the selected topic. In addition, students are expected to participate in discussion.
3. Term project (up to two students per group)
Students will apply the simulation method they have learned in class to improve the data interpretation/analysis or experimental design, or to address a specific question related to optical diagnosis/monitoring of disease/physiology.  
預期每週課後學習時數
 
Office Hours
另約時間 
參考書目
1. "Biomedical Optics: Principles and Imaging", by Lihong V. Wang and Hsin-i Wu. Wiley-Interscience, 2007.
2. "Tissue Optics: light scattering methods and instruments for medical diagnosis”, by Valery Tuchin. Bellingham, Washington: SPIE Press, 2007.
3. "Handbook of Biomedical Optics", edited by David A. Boas, Constantinos Pitris, Nimmi Ramanujam. CRC Press, 2011.
4. "Handbook of Optical Biomedical Diagnostics”, edited by Valery Tuchin. Bellingham, Washington: SPIE Press, 2016.
5. "Optical-Thermal Response of Laser-irradiated Tissue", edited by Ashley J. Welch and Martin J.C. van Gemert. New York: Plenum Press, 1995. 
指定閱讀
None 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
Literature review 
10% 
由授課教師指定各種相關技術之重要文獻,每位學生選一主題,於課堂內口頭報告,其他學生事先預習並於報告後參與討論。 
2. 
Term project proposal 
10% 
書面及口頭報告,內容包含專題目標、動機、重要性以及相關文獻與方法之探討。  
3. 
Term project 
40% 
利用作業所完成之數值模擬工具,應用於光學診斷系統之模擬或光與組織交互作用之研究。原則上兩人一組。  
4. 
Computer Homework 
40% 
使用Monte Carlo法,模擬光在組織中的傳遞。  
 
課程進度
週次
日期
單元主題
第1週
2/19  Overview 
第2週
2/26  Elastic scattering 
第3週
3/5  Monte Carlo simulation I 
第4週
3/12  Monte Carlo simulation II 
第5週
3/19  Monte Carlo simulation III 
第6週
3/26  Monte Carlo simulation IV 
第7週
4/2  溫書假 
第8週
4/9  Monte Carlo simulation V 
第9週
4/16  midterm exam 
第10週
4/23  Radiative transport equation (RTE) 
第11週
4/30  # Oral presentations - literature review
RTE - analytical solution based on diffusion approximation 
第12週
5/7  Monte Carlo simulation V 
第13週
5/14  Diffuse reflectance spectroscopy 
第14週
5/21  Fluorescence spectroscopy, Raman scattering spectroscopy 
第15週
5/28  # Oral presentations - final project proposal
Probe geometry considerations 
第16週
6/4  Near-infrared spectroscopy, diffuse optical imaging/tomography 
第17週
6/11  # Final project progress report & discussion