課程大綱

課程資訊

課程名稱	比較發生學專題討論 Seminars in Comparative Developmental Biology
開課學期	103-2
授課對象	生命科學院生命科學所
授課教師	郭典翰
課號	LS7033
課程識別碼	B21 M0490
班次
學分	2
全/半年	半年
必/選修	選修
上課時間
上課地點
備註	時地另訂，請於開學前向授課教師查詢。總人數上限：20人
Ceiba 課程網頁	http://ceiba.ntu.edu.tw/1032LS7033_
課程簡介影片
核心能力關聯	核心能力與課程規劃關聯圖
課程大綱
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課程概述	本課程所要探討的主要課題為動物胚胎發育機制的歧異度與多樣性。課程將分為兩個部分。首先，我們會一起探索早期胚胎發育過程中，不同門類動物體軸型態生成的分子機制。在課程的第二部分，我們將討論演化上保守的細胞機制如何於不同動物的形態生成過程中運作，創造動物形態的多樣性。
課程目標	(1) 認識發育機制的歧異度，並了解發育與形態多樣性的關聯。 (2) 體認歧異與多樣的背後有著一以貫之的細胞機制。 (3) 發展批判性文獻閱讀的能力。 (4) 發展學術表達的能力。
課程要求	應修過發生學或細胞學及格。最好修過無脊椎動物學。
預期每週課後學習時數
Office Hours
指定閱讀	待補
參考書目	相關主題之原始期刊論文及回顧式論文。
評量方式 (僅供參考)

課程進度

週次	日期	單元主題
第2週	03/02	Organizing meeting
第3週	03/09	Neurogenesis: Hartenstein, V., and Stollewerk, A. (2015). The evolution of early neurogenesis. Dev Cell 32, 390-407. http://dx.doi.org/10.1016/j.devcel.2015.02.004 (DHK)
第4週	03/16	Neurogenesis: Ungerer, P., Eriksson, B.J., and Stollewerk, A. (2012). Unravelling the evolution of neural stem cells in arthropods: Notch signalling in neural stem cell development in the crustacean Daphnia magna. Dev Biol 371, 302-311. http://dx.doi.org/10.1016/j.ydbio.2012.08.025 (王廣澤)
第5週	03/23	Neurogenesis: Layden, M.J., Boekhout, M., and Martindale, M.Q. (2012). Nematostella vectensis achaete-scute homolog NvashA regulates embryonic ectodermal neurogenesis and represents an ancient component of the metazoan neural specification pathway. Development 139, 1013-1022. http://dx.doi.org/10.1242/dev.073221 (DHK)
第6週	03/30	Neurogenesis: Meyer, N.P., and Seaver, E.C. (2009). Neurogenesis in an annelid: characterization of brain neural precursors in the polychaete Capitella sp. I Dev Biol 335, 237-252. http://dx.doi.org/10.1016/j.ydbio.2009.06.017 (陳思卉)
第7週	04/06	Neurogenesis: Demilly, A., Simionato, E., Ohayon, D., Kerner, P., Garces, A., and Vervoort, M. (2011). Coe genes are expressed in differentiating neurons in the central nervous system of protostomes. PLoS ONE 6, e21213. http://dx.doi.org/10.1371/journal.pone.0021213 (王登儀)
第8週	04/13	CNS: Biffar, L., and Stollewerk, A. (2015). Evolutionary variations in the expression of dorso-ventral patterning genes and the conservation of pioneer neurons in Tribolium castaneum. Dev Biol 400, 159-167. http://dx.doi.org/10.1016/j.ydbio.2015.01.025 (姜束貞)
第9週	04/20	CNS: Steinmetz, P.R.H., Urbach, R., Posnien, N., Eriksson, J., Kostyuchenko, R.P., Brena, C., Guy, K., Akam, M., Bucher, G., and Arendt, D. (2010). Six3 demarcates the anterior-most developing brain region in bilaterian animals. EvoDevo 1, 14. http://dx.doi.org/10.1186/2041-9139-1-14 (陳思卉)
第10週	04/27	CNS: Urbach, R. (2007). A procephalic territory in Drosophila exhibiting similarities and dissimilarities compared to the vertebrate midbrain/hindbrain boundary region. Neural Dev 2, 23. http://dx.doi.org/10.1186/1749-8104-2-23 (范閔翔)
第11週	05/04	CNS: Wolff, G.H., and Strausfeld, N.J. (2015). Genealogical correspondence of mushroom bodies across invertebrate phyla. Curr Biol 25, 38-44. http://dx.doi.org/10.1016/j.cub.2014.10.049 (李俊儒)
第12週	05/11	CNS: Tomer, R., Denes, A.S., Tessmar-Raible, K., and Arendt, D. (2010). Profiling by image registration reveals common origin of annelid mushroom bodies and vertebrate pallium. Cell 142, 800-809. http://dx.doi.org/10.1016/j.cell.2010.07.043 (蕭宇翔)
第13週	05/18	Spiralian: Hejnol, A., Martindale, M.Q., and Henry, J.Q. (2007). High-resolution fate map of the snail Crepidula fornicata: the origins of ciliary bands, nervous system, and muscular elements. Dev Biol 305, 63-76. http://dx.doi.org/10.1016/j.ydbio.2007.01.044 (王登儀)
第14週	05/25	Spiralian: Gline, S.E., Nakamoto, A., Cho, S.J., Chi, C., and Weisblat, D.A. (2011). Lineage analysis of micromere 4d, a super-phylotypic cell for Lophotrochozoa, in the leech Helobdella and the sludgeworm Tubifex. Dev Biol 353, 120-133. http://dx.doi.org/10.1016/j.ydbio.2011.01.031 (陶威宇)
第15週	06/01	Spiralian: Freeman, G., and Lundelius, J.W. (1992). Evolutionary implications of the mode of D quadrant specification in coelomates with spiral cleavage. J Evol Biol 5, 205-247. http://dx.doi.org/10.1046/j.1420-9101.1992.5020205.x (DHK)
第16週	06/08	Spiralian: Lambert, J.D., and Nagy, L.M. (2001). MAPK signaling by the D quadrant embryonic organizer of the mollusc Ilyanassa obsoleta. Development 128, 45-56. http://dev.biologists.org/cgi/content/abstract/128/1/45 (李俊儒)
第17週	06/15	Spiralian: Rabinowitz, J.S., and Lambert, J.D. (2010). Spiralian quartet developmental potential is regulated by specific localization elements that mediate asymmetric RNA segregation. Development 137, 4039-4049. http://dx.doi.org/10.1242/dev.055269 (姜束貞)