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Course title |
合成生物學
Synthetic Biology - Design, Engineering and Evolution |
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Semester |
109-2 |
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Designated for |
COLLEGE OF LIFE SCIENCES INSTITUTE OF LIFESCIENCE |
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Instructor |
吳亘承 |
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Curriculum Number |
LS5085 |
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Curriculum Identity Number |
B21 U2290 |
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Class |
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Credits |
2.0 |
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Full/Half
Yr. |
Half |
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Required/
Elective |
Elective |
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Time |
Thursday 6,7(13:20~15:10) |
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Room |
生科419 |
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Remarks |
與周信宏、黃筱鈞共授
The upper limit of the number of students: 18. |
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Ceiba Web Server |
http://ceiba.ntu.edu.tw/1092LS5085_ |
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Course introduction video |
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Table of Core Capabilities and Curriculum Planning |
Association has not been established |
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Course Syllabus
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Please respect the intellectual property rights of others and do not copy any of the course information without permission
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Course Description |
課堂中將講授基因選殖、誘變、演化篩選、電腦模擬與基因迴路的設計原理，與生物技術與醫學研究等相關應用。課程中，藉由互動式學習模式與學生討論經典與近期的合成生物學研究報告，學生將依研究興趣及專長分組於期末提出新的合成生物學方法或應用。 |
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Course Objective |
學生暸解合成生物學的原理及應用，透過獨立思考及團隊合作構思嶄新的實驗技術、分析方法、以及在生技產業上的應用價值。 |
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Course Requirement |
1.學生須事前閱讀教材並於課堂上積極參與討論。
2.學生須已修習普通生物學以及下列任一課程：生物化學、分子生物學、遺傳學、細胞生物學、微生物學、計算機程式設計、生物資訊學 |
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Student Workload (expected study time outside of class per week) |
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Office Hours |
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Designated reading |
待補 |
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References |
1. Synthetic Biology: Tools and Applications, 2013 (ISBN: 978-0-12-394430-6)
2. An Introduction to Systems Biology: Design Principles of Biological Circuits, 2006 (ISBN: 978-1-58488-642-6)
3. Synthetic Biology: Omics and Applications, 2018 (ISBN: 981-10-8692-3) |
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Grading |
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Week |
Date |
Topic |
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第1週 |
2/25 |
Introduction of synthetic biology |
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第2週 |
3/04 |
[Lecture_Chou] Methodology of gene cloning, mutagenesis, and selection |
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第3週 |
3/11 |
[SLP_Chou] Bioinformatic analysis of E. coli promoters |
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第4週 |
3/18 |
[SLP_Chou] Synthetic approach to characterize promoter function |
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第5週 |
3/25 |
[SLP_Chou] Building a promoter predictive model |
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第6週 |
4/01 |
溫書假 |
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第7週 |
4/08 |
[SLP_Chou] Untangling transcriptional regulation |
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第8週 |
4/15 |
[Lecture_Huang] Analysis and design of genetic networks |
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第9週 |
4/22 |
[SLP _Huang] Mutual inhibition: memory (I) |
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第10週 |
4/29 |
[SLP _Huang] Mutual inhibition: memory (II) |
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第11週 |
5/06 |
[SLP _Huang] Mutual inhibition: polarization (I) |
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第12週 |
5/13 |
[SLP _Huang] Mutual inhibition: polarization (II) |
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第13週 |
5/20 |
[Lecture_Wu] Synthetic biology meets application |
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第14週 |
5/27 |
[SLP_Wu] QS: Quorum sensing and molecular pathways |
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第15週 |
6/03 |
[SLP_Wu] QS: Synthetic cells as anti-infective strategies |
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第16週 |
6/10 |
[SLP _Wu] CRISPR: Cas9 and fundamentals |
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第17週 |
6/17 |
[SLP _Wu] CRISPR: Electrogenetic Cas9 system |